2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. IT1208

IT1208 is a humanized anti-CD4 monoclonal IgG1 antibody. IT1208 depletes CD4+ T cells with a manageable safety profile in vivo. IT1208 can be used for colon cancer research.

For research use only. We do not sell to patients.

IT1208

IT1208 Chemical Structure

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IT1208 Related Antibodies

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Description

IT1208 is a humanized anti-CD4 monoclonal IgG1 antibody. IT1208 depletes CD4+ T cells with a manageable safety profile in vivo. IT1208 can be used for colon cancer research[1][2].

Species Reactivity

Human
IC50 & Target

CD4
In Vivo

IT1208 (200 μg, i.p., twice a week for 4 weeks) improves the survival rate, alleviates typical clinical symptoms of GVHD and reduces GVHD-associated damage to key target tissues including the skin [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human B cell lymphoma Raji cells (1 × 106, i.p.) induced-mice prior to Healthy human peripheral blood mononuclear cells (PBMCs) (20 × 106, i.p.)[2]
Dosage: 200 μg
Administration: i.p., twice a week for 4 weeks
Result: Effectively prevented the development of xenogeneic GVHD in mice in experiments using cells from 3 donors.
Exerted only a partial preventive effect on xenogeneic GVHD in mice in the experiment using cells from 1 single donor.
Significantly prevented GVHD-associated damage to target tissues including the skin, salivary glands, liver and lung in mice.
Gene ID

920  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IT1208 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IT1208IT 1208IT-1208Transmembrane Glycoproteinmonoclonal antibodyCD4+ T cellscolon cancerInhibitorinhibitorinhibit

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IT1208
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HY-P991892
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