TREML1 - triggering receptor expressed on myeloid cells like 1 Gene

Also Known as TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 340205

About TREML1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,149,260-41,155,403 (from NCBI)

This gene has 4 transcripts (splice variants), 95 orthologues and 13 paralogues. Biased expression in bone marrow (RPKM 1.9), lymph node (RPKM 1.7) and 10 other tissues.

Summary

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain Orphan Receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

TREML1 Products (3)

mRNA	Protein	Name
NM_001271807.1	NP_001258736.1	trem-like transcript 1 protein isoform b precursor
NM_001271808.1	NP_001258737.1	trem-like transcript 1 protein isoform c precursor
NM_178174.4	NP_835468.1	trem-like transcript 1 protein isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15128762	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in calcium-mediated signaling	IDA IDA: Inferred from direct assay	15128762	GOA
involved in platelet activation	IEP IEP: Inferred from expression pattern	15128762	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cell surface	IDA IDA: Inferred from direct assay	15128762	GOA
located in platelet alpha granule	IDA IDA: Inferred from direct assay	15128762	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREML1 Protein Structure

V-set

0
100
200
311 a.a.

Protein Preferred Names	Protein Names
trem-like transcript 1 protein	triggering receptor expressed on myeloid cells-like protein 1

Recombinant TREML1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71382	TREML1 Protein, Human (HEK293, His)	Q86YW5 (Q16-P162)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701054	TREML1 Protein, Human (HEK293, hFc)	Q86YW5/XP_016866312.1 (Q16-P162)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Gray Platelet Syndrome	Platelet Alpha-Granule Deficiency GPS Bdplt4 Bleeding Disorder, Platelet-Type, 4 Grey Platelet Syndrome Platelet-Type Bleeding Disorder 4 Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins Deficient Alpha Granule Syndrome Platelet Alpha Granule Deficiency Platelet Granule Defect Alpha Storage Pool Deficiency Bleeding Disorder Platelet-Type 4
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease
Shwartzman Phenomenon	Shwartzman Reaction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P991029	Sutacimig	Activator	99.08%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15004	TREML1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20608	Treml1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27116	Treml1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TREML1	RGD	RGD:1565175
Macaca mulatta	TREML1	VGNC	VGNC:79250
Mus musculus	TREML1	MGD	MGI:1918576
Bos taurus	TREML1	VGNC	VGNC:36300
Felis catus	TREML1	VGNC	VGNC:66520
Others	TREML1	NCBI