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Sutacimig

(Synonyms: HMB-001)
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Based on 1 Customer Validation

Sutacimig (HMB-001) is a humanized antibody of the (H-γ4_L-κ)_(H-γ4_L-κ) format that targets FⅦa/TREML1. One arm of Sutacimig binds to endogenous FVIIa, thereby prolonging the half-life of FVIIa and increasing its accumulation in the bloodstream, while the other arm binds to TLT-1, which is exclusively expressed on the surface of activated platelets. This localizes endogenous FVIIa to activated platelets, further enhancing the activity of FVIIa. Sutacimig enhances Thrombin generation, fibrin formation, and the formation of stable fibrin-platelet networks at sites of vascular injury. Sutacimig can be used in studies related to Glanzmann thrombasthenia.

For research use only. We do not sell to patients.

  • Purity: 99.08%
  • CAS No.: 2933972-64-4
  • Molecular Weight:144.54 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sutacimig
  • Experimental Validation Results for Sutacimig
  • Experimental Validation Results for Sutacimig
  • Sutacimig Chemical Structure
    Sutacimig Chemical Structure
CAS No.: 2933972-64-4
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609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG4-kappa

  • 1/16

    Immobilized Coagulation factor VII/F7 Protein, Human (HEK293, His, HY-P78763) can bind Sutacimig. The EC50 for this effect is 10.01 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Jurkat cells with Sutacimig (HY-P991029, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Sutacimig Chemical Structure
    1/16
  • Sutacimig
  • Immobilized Coagulation factor VII/F7 Protein, Human (HEK293, His, HY-P78763) can bind Sutacimig. The EC50 for this effect is 10.01 ng/mL.
  • Flow cytometric analysis of 1.5×106 Jurkat cells with Sutacimig (HY-P991029, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • IgG4-kappa