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CELF5 - CUGBP Elav-like family member 5 Gene

Also Known as CELF-5; BRUNOL5; BRUNOL-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 60680

About CELF5

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,224,661-3,297,076 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 6 paralogues. Biased expression in brain (RPKM 14.1), ovary (RPKM 2.1) and 1 other tissue.

Summary

This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

CELF5 Products (2)

mRNA	Protein	Name
NM_001172673.2	NP_001166144.1	CUGBP Elav-like family member 5 isoform 2
NM_021938.4	NP_068757.2	CUGBP Elav-like family member 5 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	11158314	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CELF5 Protein Structure

RRM_1

0
100
200
300
400
485 a.a.

Protein Preferred Names	Protein Names
CUGBP Elav-like family member 5	CUG-BP and ETR-3 like factor 5

CELF5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CELF5	Q8N6W0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	32296183
Intra	CELF5	Q8N6W0	VASN	Homo sapiens	Q6EMK4	Y2H Array	32296183
Intra	CELF5	Q8N6W0	VASN	Homo sapiens	Q6EMK4	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	CELF5	Q8N6W0	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP9-8	Homo sapiens	Q9BYQ0	Validated Y2H	32296183
Intra	CELF5	Q8N6W0	KRTAP9-8	Homo sapiens	Q9BYQ0	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	CELF5	Q8N6W0	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	CELF5	Q8N6W0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP6-3	Homo sapiens	Q3LI67	Y2H Array	32296183
Intra	CELF5	Q8N6W0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP26-1	Homo sapiens	Q6PEX3	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	CELF5	Q8N6W0	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	CELF5	Q8N6W0	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	CELF5	Q8N6W0	PRR13	Homo sapiens	Q9NZ81	Y2H Array	32296183
Intra	CELF5	Q8N6W0	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	32296183
Intra	CELF5	Q8N6W0	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP3-2	Homo sapiens	Q9BYR7	Validated Y2H	32296183
Intra	CELF5	Q8N6W0	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183
Intra	CELF5	Q8N6W0	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Specific Language Impairment	Language Impairment, Specific

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS02463	CELF5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CELF5	VGNC	VGNC:60747
Mus musculus	CELF5	MGD	MGI:2442333
Rattus norvegicus	CELF5	RGD	RGD:1565016
Canis familiaris	CELF5	VGNC	VGNC:39096
Bos taurus	CELF5	VGNC	VGNC:55204
Macaca mulatta	CELF5	VGNC	VGNC:109597
Others	CELF5	NCBI