GS-1291269
GS-1291269 is a potent and neutral ketohexokinase (KHK) inhibitor, with IC50s of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research.
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- CAS No.: 2845278-33-1
- Formule: C20H19F5N4O2S
- Masse moléculaire:474.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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17β-HSD2 2.1 nM (IC50) |
17β-HSD5 0.38 nM (IC50) |
Chemical Information
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CAS No. 2845278-33-1
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Masse moléculaire 474.45
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Formule C20H19F5N4O2S
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SMILES
FC1(F)C2=NC(N3[C@@H](C(F)(F)F)CC3)=NC(C4=CC=C(C5(CS(C5)(=O)=O)N)C=C4)=C2CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GS-1291269 Related Classifications
HY-180921 Related Classifications
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