2845278-33-1
2845278-33-1
Chemical Structure
GS-1291269
- CAS No.: 2845278-33-1
- Formula:C20H19F5N4O2S
- Molecular Weight:474.45
InChIKey: VZPFIFNBXRYAFW-CQSZACIVSA-N
SMILES: FC1(F)C2=NC(N3[C@@H](C(F)(F)F)CC3)=NC(C4=CC=C(C5(CS(C5)(=O)=O)N)C=C4)=C2CC1
Biological Activity: GS-1291269 is a potent and neutral ketohexokinase (KHK) inhibitor, with IC50s of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research[1].
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GS-1291269 | GS-1291269 is a potent and neutral ketohexokinase (KHK) inhibitor, with IC50s of 0.38 and 2.1 nM against KHK-C and KHK-A, respectively. GS-1291269 demonstrates liver and kidney fructose-1-phosphate (F1P) reduction in a fructose challenge model in rats. GS-1291269 can be used for kidney disease and metabolic-dysfunction-associated steatotic liver disease (MASLD) research. | |||||||||||||||||||||
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References
Keywords
