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Cat. No.: HY-159088

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KOR agonist 2

KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with K_i of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED₅₀ of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes.

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CAS No.: 3050912-29-0
Formule: C₂₉H₃₅ClN₂O₄S
Masse moléculaire:543.12

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

KOR agonist 2 Chemical Structure

CAS No.: 3050912-29-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- IC₅₀ & Target
Chemical Information
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Activité biologique

Description

IC₅₀ & Target

κ Opioid Receptor/KOR

1.9 nM (Ki)

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Chemical Information

CAS No. 3050912-29-0
Masse moléculaire 543.12
Formule C₂₉H₃₅ClN₂O₄S
SMILES

O=S(C1=CC=CC(Cl)=C1)(N(CC2=CC=CC=C2)[C@@H]3C[C@H](CN(C)C)[C@](C4=CC=CC(OC)=C4)(O)CC3)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Gao Y, et al., Discovery of N'-benzyl-3-chloro-N-((1S,3R,4R)-3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)cyclohexyl)benzenesulfonamide as a novel selective KOR ligand. Eur J Med Chem. 2024 Jul 3;276:116643. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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KOR agonist 2

Voir tous les produits spécifiques à Isoform Opioid Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

KOR agonist 2 Related Classifications

HY-159088 Related Classifications