3050912-29-0
3050912-29-0
Chemical Structure
KOR agonist 2
- CAS No.: 3050912-29-0
- Formula:C29H35ClN2O4S
- Molecular Weight:543.12
InChIKey: OHPHGELLPXLCDW-AZIXZEHSSA-N
SMILES: O=S(C1=CC=CC(Cl)=C1)(N(CC2=CC=CC=C2)[C@@H]3C[C@H](CN(C)C)[C@](C4=CC=CC(OC)=C4)(O)CC3)=O
Biological Activity: KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes[1].
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KOR agonist 2 | KOR agonist 2 (Compound 23p) is an agonist for κ opioid receptor (KOR) with Ki of 1.9 nM. KOR agonist 2 exhibits analgesic effect in mouse models with ED50 of 1.30 mg/kg. KOR agonist 2 exhibits high clearance rate (2 mg/kg, i.v.) in mice, high metabolism and clearance in liver microsomes. | |||||||||||||||||||||
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References
Keywords
