MMG-0358
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4.
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- CAS No.: 1378976-02-3
- Formule: C8H6ClN3O
- Masse moléculaire:195.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
|
IDO1 330 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.082 μM
Compound: MMG-0358
|
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrs
|
[PMID: 31525930] |
| P815 | IC50 |
>100 μM
Compound: 35, MMG-0358
|
Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysis
|
[PMID: 22616902] |
| P815 | IC50 |
0.002 μM
Compound: 35, MMG-0358
|
Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysis
|
[PMID: 22616902] |
Chemical Information
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CAS No. 1378976-02-3
-
Masse moléculaire 195.61
-
Formule C8H6ClN3O
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SMILES
ClC1=CC(C2=CN=NN2)=C(O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)