Mutated EGFR-IN-2
Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=＜1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity.
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- CAS No.: 2050906-97-1
- Formule: C29H35FN8O3
- Masse moléculaire:562.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Activité biologique
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EGFRT790M |
EGFRL858R |
EGFRex19del |
EGFR (L858R/T790M) <1 nM (IC50) |
EGFR (ex19del/T790M) |
Chemical Information
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CAS No. 2050906-97-1
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Masse moléculaire 562.64
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Formule C29H35FN8O3
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SMILES
C=CC(NC1=CC(NC2=NC=CC(N3C4=CC=C(F)C=C4N(C(C)C)C3=O)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mutated EGFR-IN-2 Related Classifications
HY-128860 Related Classifications
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