RIPK1-IN-16
RIPK1-IN-16 is an orally active and potent inhibitor of RIPK1. RIPK1-IN-16 inhibits excessive inflammation by blocking RIPK1-mediated necroptosis in vivo. RIPK1-IN-16 protects mouse from TNF-induced systemic inflammatory response syndrome and sepsis.
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- CAS No.: 2561431-77-2
- Formule: C20H19N5O2S
- Masse moléculaire:393.46
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | CC50 |
>100 μM
Compound: 1
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured for 16 to 24 hrs by Cell-titer-glo assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured for 16 to 24 hrs by Cell-titer-glo assay
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[PMID: 36724216] |
| HT-29 | CC50 |
>50 μM
Compound: 11
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 8 to 10 hrs by celltiter-glo luminescent cell viability assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability measured after 8 to 10 hrs by celltiter-glo luminescent cell viability assay
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[PMID: 33930803] |
| HT-29 | CC50 |
>50 μM
Compound: 1
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Cytotoxicity against human HT-29 cells assessed as reduction in cell viability
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability
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[PMID: 35398729] |
| HT-29 | EC50 |
0.0028 μM
Compound: 11
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Anti-necroptotic activity in human HT-29 cells assessed as inhibition of hTNFalpha/Z-VAD-fmk (TSZ)-induced necroptosis by measuring increase in cell viability measured after 8 to 10 hrs by celltiter-glo luminescent cell viability assay
Anti-necroptotic activity in human HT-29 cells assessed as inhibition of hTNFalpha/Z-VAD-fmk (TSZ)-induced necroptosis by measuring increase in cell viability measured after 8 to 10 hrs by celltiter-glo luminescent cell viability assay
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[PMID: 33930803] |
| HT-29 | EC50 |
2.8 nM
Compound: 1
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Anti-necroptosis activity against human HT-29 cells assessed as inhibition of TSZ-induced necroptosis preincubated for 30 mins followed by compound addition and measured for 16 hrs by Cell-titer-glo assay
Anti-necroptosis activity against human HT-29 cells assessed as inhibition of TSZ-induced necroptosis preincubated for 30 mins followed by compound addition and measured for 16 hrs by Cell-titer-glo assay
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[PMID: 36724216] |
Chemical Information
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CAS No. 2561431-77-2
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Masse moléculaire 393.46
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Formule C20H19N5O2S
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SMILES
CN1C2=CC=CC=C2OC[C@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)C1=S
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RIPK1-IN-16 Related Classifications
HY-156367 Related Classifications
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