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Cat. No.: HY-146338

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RPR103611

RPR103611, the betulinic acid derivative, is a potent HIV-1 entry inhibitor with IC₅₀s of 80, 0.27, and 0.17 for CCR5-tropic virus YU2, CXCR4-tropic virus NL4-3 and dual tropic virus 89.6, respectively.

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CAS No.: 150840-75-8
Formule: C₄₆H₇₈N₂O₆
Masse moléculaire:755.12

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

RPR103611 Chemical Structure

CAS No.: 150840-75-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
H9	EC₅₀	0.03 μM Compound: 12	Toxic concentration on HIV-1 mock infected H9 lymphocyte cells Toxic concentration on HIV-1 mock infected H9 lymphocyte cells	[PMID: 8676334]
H9	IC₅₀	2.7 μM Compound: 12	Inhibitory activity against HIV-1 replication in mock infected H9 cells Inhibitory activity against HIV-1 replication in mock infected H9 cells	[PMID: 8676334]
TZM	CC₅₀	17 μM Compound: 2; RPR103611	Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability by CellTitre-Glo assay Cytotoxicity against human TZM-bl cells assessed as reduction in cell viability by CellTitre-Glo assay	[PMID: 35513221]

Chemical Information

CAS No. 150840-75-8
Masse moléculaire 755.12
Formule C₄₆H₇₈N₂O₆
SMILES

[H][C@@]12CC[C@@]3([C@](CC[C@@]4([C@]5([C@@H](CC[C@@]5(CC[C@]43C)C(NCCCCCCCC(N[C@H]([C@H](CC(O)=O)O)CC(C)C)=O)=O)C(C)=C)[H])[H])([C@]1(CC[C@@H](C2(C)C)O)C)[H])C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Reon Takeuchi, et al. Design, synthesis, and bio-evaluation of novel triterpenoid derivatives as anti-HIV-1 compounds. Bioorg Med Chem Lett. 2022 Aug 1;69:128768. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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RPR103611

Voir tous les produits spécifiques à Isoform HIV

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

RPR103611 Related Classifications

HY-146338 Related Classifications