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Cat. No.: HY-113737

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Trichlorfon ethyl

Trichlorfon ethyl is an analog of Trichlorfon (HY-B1220), as well as an inhibitor of Butyrylcholinesterase and Bacillus subtilis Esterase. Trichlorfon ethyl acts as a prenatal brain growth inhibitor, causing mild reductions in total brain weight, medulla oblongata weight and tectum weight in newborn guinea pigs, without affecting cerebellar weight. Trichlorfon ethyl does not induce severe prenatal brain hypoplasia in guinea pig offspring. Trichlorfon ethyl can be used in studies related to brain hypoplasia.

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CAS No.: 993-86-2
Formule: C₆H₁₂Cl₃O₄P
Masse moléculaire:285.49

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Please store the product under the recommended conditions in the Certificate of Analysis.

Trichlorfon ethyl Chemical Structure

CAS No.: 993-86-2

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Description

IC₅₀ & Target^[2]

BChE

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

In Vitro

Trichlorfon ethyl (Compound Ih) (0.1 mM; 1-10 min) inhibits butyrylcholinesterase from horse blood serum with a k_II of 2.75×10³ L mol^-1 min^-1 and Bacillus subtilis esterase with a k_II of 4.06×10² L mol^-1 min^-1^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Trichlorfon ethyl (121-138 mg/kg; single dose on gestational days 42, 44, 45, 46) produces only minimal, dose-dependent reductions in specific offspring brain region weights in pregnant guinea pigs treated during mid-gestation, with no significant effect on cerebellum weight at tested doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Outbred albino guinea pigs (Ssc:AL, Mol:DHF; pregnant dams)^[1]
Dosage:

125 mg/kg (gestational days 44, 45, 46); 138 mg/kg (gestational day 42); 121 mg/kg (gestational day 44)
Administration:

Single dose on specified gestational days
Result:

Showed no significant reductions in total brain weight or weights of cerebellum, medulla oblongata, diencephalon, hippocampus, quadrigemina, or cerebral cortex in offspring exposed to 125 mg/kg, compared to saline controls.
Showed a significant reduction in total brain weight (mean 2.47 g, p < 0.05), medulla oblongata weight (mean 163 mg, p < 0.05), and quadrigemina weight (mean 73 mg, p < 0.05), but no significant reduction in cerebellum weight in offspring exposed to 138 mg/kg (day 42) and 121 mg/kg (day 44).
Reduced red blood cell acetylcholinesterase activity to 51% of control levels 24 hours after administration of 125 mg/kg.
Observed no significant changes in glutamate decarboxylase, choline acetyltransferase, or acetylcholinesterase activities in cerebellum, medulla, or cerebral cortex of offspring exposed to ethyl-trichlorfon.

Chemical Information

CAS No. 993-86-2
Masse moléculaire 285.49
Formule C₆H₁₂Cl₃O₄P
SMILES

ClC(Cl)(C(O)P(OCC)(OCC)=O)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Mehl A, et al. The effect of trichlorfon and other organophosphates on prenatal brain development in the guinea pig. Neurochemical research. 1994 May;19(5):569-74. [Content Brief]

[2]. Krutikova V V, et al. Polyfluoroalloxy phosphonic and phosphinic acid derivatives: I. 1-Hydroxy-2, 2, 2-trichloroethylphosphinates[J]. Russian Journal of General Chemistry, 2010, 80(3): 428-433.

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Trichlorfon ethyl

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE)

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Chemical Information

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Trichlorfon ethyl Related Classifications

HY-113737 Related Classifications