1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. CHM-1

CHM-1 (Synonyms: NSC656158)

Cat. No.: HY-103257
Handling Instructions

CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity.

For research use only. We do not sell to patients.

CHM-1 Chemical Structure

CHM-1 Chemical Structure

CAS No. : 154554-41-3

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Description

CHM-1, a microtubule-destabilizing agent, inhibits tubulin polymerization. CHM-1 is a potent and selective antimitotic antitumor activity against human hepatocellular carcinoma. CHM-1 induces growth inhibition and apoptosis via G2-M phase arrest in human hepatocellular carcinoma cells by activation of Cdc2 kinase activity[1][2][3].

IC50 & Target

IC50: 0.75 μM (HA22T)[1]

In Vitro

CHM-1 (0-100μM; 24 hours) induces significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells (IC50 = 0.75 μM)[1].
CHM-1 (0-10 μM; 24 hours) significantly increases the binding of cyclin B1 to Cdc2 in HA22T cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HA22T, Hep3B, and HepG2 cells
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: Induced G2-M arrest of the cell cycle followed by apoptosis.

Western Blot Analysis[1]

Cell Line: HA22T cells
Concentration: 0-10 μM
Incubation Time: 24 hours
Result: Induced change in expressed and phosphorylated status of G2-M regulators in human hepatocellular carcinoma cells.
In Vivo

CHM-1 (10 mg/kg; I.p.) induces a dose-dependent inhibition of HA22T tumor growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male severe combined immunodeficient mice (HA22T)[1]
Dosage: 10 mg/kg
Administration: I.p.
Result: Induced a dose-dependent inhibition of HA22T tumor growth.
Molecular Weight

283.25

Formula

C₁₆H₁₀FNO₃

CAS No.
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Storage

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CHM-1
Cat. No.:
HY-103257
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