2. Metabolic Enzyme/Protease
  3. HIV Integrase
  4. D719

D719 is an HIV-1 integrase inhibitor. D719 binds to the hydrophobic pocket of HIV-1 integrase CCD dimer, disrupts interaction with LEDGF/P75, and prevents integrase nuclear translocation. D719 reduces HIV-1 p24 antigen production in acute infection of human T cells. D719 can be used for the research of HIV infection.

For research use only. We do not sell to patients.

D719

D719 Chemical Structure

CAS No. : 384361-09-5

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D719 Related Antibodies

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Description

D719 is an HIV-1 integrase inhibitor. D719 binds to the hydrophobic pocket of HIV-1 integrase CCD dimer, disrupts interaction with LEDGF/P75, and prevents integrase nuclear translocation. D719 reduces HIV-1 p24 antigen production in acute infection of human T cells. D719 can be used for the research of HIV infection[1].

In Vitro

D719 (1 μM; from 5 h post-transfection until fixation the next day) inhibits nuclear translocation of EGFP-tagged HIV-1 integrase in HeLa Tet-Off Advanced Cells[1].
D719 (10 μM; from 5 h post-transfection until fixation the next day) inhibits nuclear translocation of native HIV-1 integrase in HeLa Tet-Off Advanced Cells[1].
D719 (0.5-20 μM; 3 days post-infection) inhibits HIV-1 replication in acutely infected C8166 T cells, reducing p24 antigen production with an EC50 of 4.33 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D719 Related Antibodies

Immunofluorescence[1]

Cell Line: HeLa Tet-Off Advanced Cells
Concentration: 10 μM
Incubation Time: from 5 h post-transfection until fixation the next day
Result: Prevented native integrase from localizing to the nucleus, confirming inhibition of nuclear translocation independent of EGFP interactions.
Molecular Weight

412.46

Formula

C21H20N2O5S
CAS No.
SMILES

O=C1OC2=C(CN(CCO)CCO)C(O)=CC=C2C=C1C3=NC4=C(S3)C=CC=C4
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References
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D719 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D719384361-09-5D 719D-719HIV IntegraseLEDGF/P75human immunodeficiency virus (HIV)C8166 T cellshuman T cellsHIV-1 integrase CCD dimerHIV-1 integraseHeLa Tet-Off Advanced CellsHIV-1 replicationHIV-1 p24 antigenInhibitorinhibitorinhibit

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