384361-09-5
384361-09-5
Chemical Structure
D719
- CAS No.: 384361-09-5
- Formula:C21H20N2O5S
- Molecular Weight:412.46
InChIKey: JPUPOZFSPRTBRC-UHFFFAOYSA-N
SMILES: O=C1OC2=C(CN(CCO)CCO)C(O)=CC=C2C=C1C3=NC4=C(S3)C=CC=C4
Biological Activity: D719 is an HIV-1 integrase inhibitor. D719 binds to the hydrophobic pocket of HIV-1 integrase CCD dimer, disrupts interaction with LEDGF/P75, and prevents integrase nuclear translocation. D719 reduces HIV-1 p24 antigen production in acute infection of human T cells. D719 can be used for the research of HIV infection[1].
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D719 | D719 is an HIV-1 integrase inhibitor. D719 binds to the hydrophobic pocket of HIV-1 integrase CCD dimer, disrupts interaction with LEDGF/P75, and prevents integrase nuclear translocation. D719 reduces HIV-1 p24 antigen production in acute infection of human T cells. D719 can be used for the research of HIV infection. | |||||||||||||||||||||
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References
Keywords
