AB21 hydrochloride
Based on 1 Customer Validation
AB21 hydrochloride is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 hydrochloride has the effect of reducing mechanical hypersensitivity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.92%
- CAS. Nr.: 3026677-24-4
- Formel: C23H29ClN2O
- Molecular Weight:384.94
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Biologische Aktivität
AB21 hydrochloride shows Kis of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Capsaicin-induced mechanical hypersensitivity model in mice[1].
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Dosage:20 mg/kg
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Administration:Subcutaneous injection (s.c.); administered 30 min before the injection of capsaicin.
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Result:Result: Showed complete reversal of the mechanical hypersensitivity reaction and the dose administered was half that of BD-1063 (40 mg/kg).
Chemical Information
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CAS. Nr. 3026677-24-4
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Appearance Solid
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Molecular Weight 384.94
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Formel C23H29ClN2O
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Color White to off-white
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SMILES
O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
DMSO : 8.33 mg/mL (21.64 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5978 mL | 12.9890 mL | 25.9781 mL | 64.9452 mL |
| 5 mM | 0.5196 mL | 2.5978 mL | 5.1956 mL | 12.9890 mL | |
| 10 mM | 0.2598 mL | 1.2989 mL | 2.5978 mL | 6.4945 mL | |
| 15 mM | 0.1732 mL | 0.8659 mL | 1.7319 mL | 4.3297 mL | |
| 20 mM | 0.1299 mL | 0.6495 mL | 1.2989 mL | 3.2473 mL |
AB21 hydrochloride Related Classifications
HY-149854B Related Classifications
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