AB21
AB21 is a potent and selective S1R antagonist with Kis of 13, 102 nM for S1R and S2R. AB21 has the effect of reducing mechanical hypersensitivity.
For research use only. We do not sell to patients.
- CAS No.: 3026677-23-3
- Formula: C23H28N2O
- Molecular Weight:348.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Sigma Receptor Isoforms
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Biological Activity
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Sigma 1 Receptor 13 nM (Ki) |
Sigma 2 Receptor 102 nM (Ki) |
AB21 shows Kis of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Capsaicin-induced mechanical hypersensitivity model in mice[1]
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Dosage:20 mg/kg
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Administration:Subcutaneous injection (s.c.); administered 30 min before the injection of capsaicin
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Result:Result: Showed complete reversal of the mechanical hypersensitivity reaction and the dose administered was half that of BD-1063 (40 mg/kg).
Chemical Information
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CAS No. 3026677-23-3
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Molecular Weight 348.48
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Formula C23H28N2O
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SMILES
O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AB21 Related Classifications
HY-149854 Related Classifications
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