AB21

Cat. No.: HY-149854: FAQs
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AB21 is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 has the effect of reducing mechanical hypersensitivity.

For research use only. We do not sell to patients.

AB21 Chemical Structure

CAS No. : 3026677-23-3

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Other Forms of AB21:

AB21 oxalate Get quote

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Description

AB21 is a potent and selective S1R antagonist with K_is of 13, 102 nM for S1R and S2R. AB21 has the effect of reducing mechanical hypersensitivity^[1].

IC₅₀ & Target^[1]

Sigma 1 Receptor

13 nM (Ki)

Sigma 2 Receptor

102 nM (Ki)

In Vitro

AB21 shows K_is of 12 nM and 14 nM with or without Phenytoin in the S1R Radioligand Binding Assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AB21 (20 mg/kg, s.c., administered 30 min before the injection of Capsaicin (HY-10448)) reverses mechanical allodyniain in Capsaicin (HY-B0448)-induced pain model, and exhibits higher potency than BD1063 dhydrochloride (HY-18101A)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Capsaicin-induced mechanical hypersensitivity model in mice^[1]
Dosage:	20 mg/kg
Administration:	Subcutaneous injection (s.c.); administered 30 min before the injection of capsaicin
Result:	Result: Showed complete reversal of the mechanical hypersensitivity reaction and the dose administered was half that of BD-1063 (40 mg/kg).

Molecular Weight

348.48

Formula

C₂₃H₂₈N₂O

CAS No.

3026677-23-3

SMILES

O=C(N(CC1)CCC21CN(CCC3=CC=CC=C3)C2)CC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dichiara M, et al. Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS Chem Neurosci. 2023 May 17;14(10):1845-1858. [Content Brief]

AB21 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB213026677-23-3AB 21AB-21Sigma ReceptorS1R antagonistCapsaicin-induced mechanical hypersensitivityInhibitorinhibitorinhibit

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