Dspp - dentin sialophosphoprotein Gene

Also Known as Dpp; Dsp; Dmp2; Dmp3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 666279

Summary

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mice lacking the encoded protein exhibit hypomineralization defects in dentin, similar to human dentinogenesis imperfecta. [provided by RefSeq, Feb 2016]

Dspp Products (1)

mRNA Protein Name
NM_010080.3 NP_034210.2 dentin sialophosphoprotein preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
23525114 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within S-shaped body morphogenesis IMP
IMP: Inferred from mutant phenotype
16937369 MGI
acts upstream of or within ameloblast differentiation IMP
IMP: Inferred from mutant phenotype
25027178 MGI
acts upstream of or within amelogenesis IMP
IMP: Inferred from mutant phenotype
25027178 MGI
acts upstream of or within branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
16937369 MGI
acts upstream of or within cellular response to cell-matrix adhesion IDA
IDA: Inferred from direct assay
17286598 MGI
acts upstream of or within connective tissue development IMP
IMP: Inferred from mutant phenotype
25027178 MGI
acts upstream of or within dentinogenesis IMP
IMP: Inferred from mutant phenotype
25027178 MGI
acts upstream of or within endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
26972716 MGI
acts upstream of or within gene expression involved in extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
23900597 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
16937369 MGI
acts upstream of or within mandibular condyle articular cartilage development IMP
IMP: Inferred from mutant phenotype
23900597 MGI
acts upstream of or within mesenchymal to epithelial transition IMP
IMP: Inferred from mutant phenotype
16937369 MGI
acts upstream of or within negative regulation of bone development IMP
IMP: Inferred from mutant phenotype
26972716 MGI
acts upstream of or within negative regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
25027178 MGI
acts upstream of or within negative regulation of growth plate cartilage chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
26972716 MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process IMP
IMP: Inferred from mutant phenotype
16937369 MGI
acts upstream of or within odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
25027178 MGI
acts upstream of or within odontogenesis IMP
IMP: Inferred from mutant phenotype
25027178 MGI
acts upstream of or within positive regulation of chondrocyte proliferation IMP
IMP: Inferred from mutant phenotype
23900597 MGI
acts upstream of or within positive regulation of enamel mineralization IDA
IDA: Inferred from direct assay
16014627 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
19001636 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
25027178 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19001636 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dentin sialophosphoprotein

  • DMP-3

  • dentin matrix protein 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P3386A Selcopintide acetate 99.63% Unkown
HY-P3386 Selcopintide / Unkown
HY-RS04027 DSPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Y0332L Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340 Activator / Unkown
HY-RS21329 Dspp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27848 Dspp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dspp NCBI NCBI:1834