2. Peptides
  3. Selcopintide

Selcopintide (Cpne7-DP) consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Selcopintide acetate) usually boasts enhanced water solubility and stability.

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Selcopintide Chemical Structure

Selcopintide Chemical Structure

CAS No. : 2130912-34-2

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Other Forms of Selcopintide:

Selcopintide Related Antibodies

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Description

Selcopintide (Cpne7-DP) consists of a synthetic peptide corresponding to the 10 amino acid residue 344-353 fragment of the hCPNE7 protein. Selcopintide highly reproduces the in vitro effects of CPNE7 by upregulating odontoblast marker genes, DSPP, and Nestin. Selcopintide promotes dentin regeneration in dentinal defects of various degrees and that the regenerated hard tissue demonstrates the characteristics of true dentin[1].

In Vitro

Selcopintide (Cpne7-DP) directly penetrates odontoblastic cell (MDPC-23 cells) [1].
Selcopintide (1, 10 μg) increases dspp promoter activity in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Selcopintide Related Antibodies
In Vivo

Selcopintide (Cpne7-DP; human DPCs with 10 µg subcutaneous transplantation in a 0.5% fibrin gel) promotes dentin-like tissue formation and the regeneration of tubular dentin and dentinal tubule occlusion in shallow and deep cavity models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immunocompromised mice (NIH-bg-nu-xid)[1]
Dosage: 10 µg
Administration: Subcutaneous transplantation in a 0.5% fibrin gel
Result: Promotes dentin-like tissue formation.
Promotes the regeneration of tubular dentin and dentinal tubule occlusion in shallow and deep cavity models.
Molecular Weight

1384.63

Formula

C62H105N21O15
CAS No.
Sequence

Lys-Tyr-Lys-Gln-Lys-Arg-Arg-Ser-Tyr-Lys
Sequence Shortening

KYKQKRRSYK
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selcopintide2130912-34-2Cpne7-DPOthersodontoblastic cellCPNE7-derived peptidetubular orthodentinperitubular dentin formationInhibitorinhibitorinhibit

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