DSPP - dentin sialophosphoprotein Gene

Also Known as DPP; DSP; DGI1; DMP3; DFNA39

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1834

About DSPP

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,608,529-87,616,873 (from NCBI)

This gene has 1 transcript (splice variant), 71 orthologues and is associated with 10 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of proteins. The encoded preproprotein is secreted by odontoblasts and proteolytically processed to generate two principal proteins of the dentin extracellular matrix of the tooth, dentin sialoprotein and dentin phosphoprotein. These two protein products may play distinct but related roles in dentin mineralization. Mutations in this gene are associated with dentinogenesis imperfecta and dentin dysplasia. This gene is present in a gene cluster on chromosome 4. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jan 2016]

DSPP Products (1)

mRNA	Protein	Name
NM_014208.3	NP_055023.2	dentin sialophosphoprotein preproprotein

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11856645	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dentin sialophosphoprotein	deafness, autosomal dominant 39

Related Diseases

Diseases	Alias
Dentinogenesis Imperfecta 1	Capdepont Teeth Dentinogenesis Imperfecta Type 2 Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi-Ii Dentinogenesis Imperfecta, Shields Type 2 DGI1 Opalescent Teeth Without Osteogenesis Imperfecta Dentinogenesis Imperfecta, Shields Type Ii Dgi-2 Di-2 DGI2 Dentinogenesis Imperfecta Shields Type Ii Non-Syndromic Dentinogenesis Imperfecta Non-Syndromic Dgi
Dentinogenesis Imperfecta, Shields Type Iii	Dentinogenesis Imperfecta Type 3 Brandywine Type Dentinogenesis Imperfecta Dentinogenesis Imperfecta, Shields Type 3 Dgi-Iii Dentinogenesis Imperfecta Shields Type 3 Dentinogenesis Imperfecta Type Iii DGI3
Dentin Dysplasia, Type Ii	DTDP2 Coronal Dentin Dysplasia Anomalous Dysplasia Of Dentin Pulpal Dysplasia Pulp Stones Dentin Dysplasia, Coronal Dd-Ii Dentin Dysplasia Type Ii Dentin Dysplasia, Shields Type Ii Dentin Dyspalsia, Shields Type 2 Dentin Dysplasia 2 Dentin Dysplasia Shields Type Ii Dysplasia, Dentin, Type 2 Dental Pulp Stone
Deafness, Autosomal Dominant 39, With Dentinogenesis Imperfecta 1	Dfna39/Dentinogenesis Imperfecta 1 Syndrome Dfna39/Dgi1 Syndrome Dgi1/Dfna39 Syndrome Deafness, Autosomal Dominant 39, With Dentinogenesis Deafness, Autosomal Dominant, 39, With Dentinogenesis Imperfecta 1 DFNA39/DGI1 Deafness, Autosomal Dominant, Type 39, With Dentinogenesis
Dentinogenesis Imperfecta	Hereditary Opalescent Dentin Dentinogenesis Imperfecta Without Osteogenesis Imperfecta Dgi Capdepont Teeth Dgi Without Oi Di Non-Syndromic Dgi Non-Syndromic Dentinogenesis Imperfecta Opalescent Teeth Without Oi Opalescent Teeth Without Osteogenesis Imperfecta Opalescent Dentin
Dentin Dysplasia, Type I	Radicular Dentin Dysplasia DTDP1 Rootless Teeth Dentin Dysplasia Type I Dd-I Dentin Dysplasia Shields Type I Dentin Dysplasia, Shields Type I Dentin Dysplasia, Type I, With Microdontia And Misshapen Teeth Dentin Dysplasia, Type 1 Atypical Dentin Dysplasia Due To Smoc2 Deficiency Dentin Dysplasia Type 1 With Microdontia And Shape Anomalies Dentin Dysplasia, Radicular Dentin Dysplasia 1 Dentin Dysplasia 1, With Extreme Microdontia And Misshapen Teeth DTDP1-MMT Dentin Dysplasia, Type I, With Extreme Microdontia And Misshapen Teeth Dysplasia, Dentin, Type I
Dentin Dysplasia	Dentinal Dysplasia Dd Dysplasia, Dentin Shell Teeth
Dentin Sensitivity	Sensitive Dentin
Root Caries	Cementum Caries Dental Caries Of Root Surface
Tooth Resorption
Regional Odontodysplasia	Ghost Teeth Odontodysplasia
Dental Pulp Necrosis	Pulp Necrosis Necrotic Pulp Necrosis Of The Pulp Dead Pulp Devitalised Pulp Putrescent Pulpitis Devitalized Tooth Dental Pulp Gangrene Pulp Gangrene Nonvital Tooth Pulpless Tooth Putrescent Pulp
Dental Caries	Dental Caries Extending Into Pulp Dental Caries Of Smooth Surface Dental Caries Pit And Fissure Smooth Surface Dental Caries Dental Decay Carious Teeth Dental Cavity Saprodontia Teeth Decayed Tooth Caries Tooth Decay
Pulp Degeneration	Degeneration Of Dental Pulp
Periapical Periodontitis	Apical Periodontitis Periodontitis Apical
Pulpitis	Pulp Stones Pulpitis Nos
Root Resorption
Suppurative Periapical Periodontitis	Periapical Abscess Apical Abscess Suppurative Apical Periodontitis Dentoalveolar Abscess Dental Abscess With Sinus Dentoalveolar Abscess With Sinus Dental Sinus Periapical Abscess Fistula Apical Tooth Abscess Apex Abscess Dental Abscess Nos Infection Of Tooth Nos Abscess Of Tooth Dental Infection Nos
Hypercementosis	Cementation Hyperplasia
Dens Evaginatus
Tooth Erosion	Generalized Erosion Localized Erosion Generalized Erosions Erosion, Localized
Dental Pulp Calcification	Pulp Calcification Pulp Calcifications Pulpal Calcifications Dental Pulp Stone
Gingival Recession	Localized Gingival Recession Gingival Recession, Localized Minimal Gingival Recession Moderate Gingival Recession Severe Gingival Recession Gingival Recession, Minimal Gingival Recession, Severe Atrophy Of Gums Gum Atrophy Gingival Atrophy
Teeth, Fused	Fused Teeth
Odontoma
Dental Pulp Disease	Dental Pulp Diseases Dental Pulp Disorder Disorder Of Pulp Of Tooth Pulp Disorder
Hypophosphatemia	Vitamin D-Resistant Rickets Hereditary Hypophosphatemic Rickets Vdrr Vitamin D Resistant Rickets Hypophosphatemic Rickets, X-Linked Dominant Familial Hypophosphatemic Rickets
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Hypophosphatasia	Phosphoethanolaminuria Childhood Hypophosphatasia Deficiency Of Alkaline Phosphatase Hypophospatasia, Childhood Hypophosphatasia Mild Phosphoethanol-Aminuria Rathburn Disease Hpp Rathbun Disease Hypophosphatasia, Childhood Infantile Hypophosphatasia
Taurodontism	Bull Teeth Large Pulp Chambers In The Molars
Rickets	Vitamin D Deficiency Vitamin D Active Rickets Hypovitaminosis D Nutritional Rickets Vitamin D Deficiency Disease Vitamin-D Deficiency Rickets Vitamin D-Dependent Rickets Avitaminosis D Infantile Osteomalacia Juvenile Osteomalacia
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Teeth, Supernumerary	Supernumerary Teeth
Teeth Hard Tissue Disease
Hypophosphatemic Rickets, X-Linked Recessive	Hypophosphatemic Rickets X-Linked Recessive Hypophosphatemic Rickets XLRHR Hypophosphatemic Rickets Disorders Rickets Hypophosphatemic Rickets, Hypophosphatemic, X-Linked Recessive Familial Hypophosphatemic Rickets
Dentin Caries	Compound Dental Caries Dental Caries Extending Into Dentine Dental Caries Extending Into Dentin
Autosomal Recessive Hypophosphatemic Rickets	Arhr Hypophosphatemic Rickets, Autosomal Recessive Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Ehlers-Danlos Syndrome, Classic Type, 1	Ehlers-Danlos Syndrome, Type I EDSCL1 Ehlers-Danlos Syndrome Classic Type 1 Ehlers-Danlos Syndrome Type 1 Ehlers-Danlos Syndrome, Type I, Formerly Eds1, Formerly Ehlers-Danlos Syndrome, Severe Classic Type, Formerly Eds I, Formerly Ehlers-Danlos Syndrome, Gravis Type, Formerly Ehlers-Danlos Syndrome, Type 1 Type I Ehlers-Danlos Syndrome Eds1 Eds I Ehlers-Danlos Syndrome, Gravis Type Ehlers-Danlos Syndrome, Severe Classic Type Ehlers-Danlos Syndrome 1 Ehlers-Danlos, Classic Syndrome, Type 1 Ehlers-Danlos Syndrome Type 2
Geotrichosis
Osteogenesis Imperfecta, Type Iv	Osteogenesis Imperfecta Type 4 Osteogenesis Imperfecta Type Iv OI4 Oi, Type Iv Osteogenesis Imperfecta With Normal Sclerae Oi Type Iv Oi Type 4 Osteogenesis Imperfecta With Normal Sclera Common Variable Oi With Normal Sclerae Osteogenesis Imperfecta 4 Oi-Iv
Hypophosphatemic Rickets, X-Linked Dominant	X-Linked Hypophosphatemia Xlh Vitamin D-Resistant Rickets, X-Linked X-Linked Hypophosphatemic Rickets XLHR Hyp Hypophosphatemic Vitamin D-Resistant Rickets Hpdr X-Linked Dominant Hypophosphatemic Rickets Familial Hypophosphatemic Rickets Hypophosphatemia, X-Linked Hypophosphatemia, Vitamin D-Resistant Rickets Hypophosphatemic Rickets X-Linked Dominant X-Linked Vitamin D-Resistant Rickets Hypophophatemia, X-Linked Hypophophatemic Vitamin D-Resistant Rickets Hypophosphatemia X-Linked Vitamin D-Resistant Rickets X-Linked Vitamin D-Resistant Rickets Rickets, X-Linked Hypophosphatemic
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3386A	Selcopintide acetate		99.63%	Unkown
HY-P3386	Selcopintide		/	Unkown
HY-RS04027	DSPP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-Y0332L	Potassium dihydrogen phosphate, meets analytical specification of Ph. Eur., NF, E340	Activator	/	Unkown
HY-RS21329	Dspp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27848	Dspp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DSPP	MGD	MGI:109172
Felis catus	DSPP	VGNC	VGNC:78482
Bos taurus	DSPP	VGNC	VGNC:106717
Rattus norvegicus	DSPP	RGD	RGD:2525
Others	DSPP	NCBI