country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-186205

Copy Link Print Information

(Rac)-EGC-M5

(Rac)-EGC-M5 is an orally active metabolite of green tea Catechin (EGC) (HY-N0898). (Rac)-EGC-M5 enhances the activity of CD4⁺ T cells. (Rac)-EGC-M5 boosts the cytotoxic activity of NK cells in vivo. (Rac)-EGC-M5 can be used in cancer-related research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1299471-83-2
Formel: C₁₁H₁₂O₄
Molecular Weight:208.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-EGC-M5 Chemical Structure

CAS. Nr.: 1299471-83-2

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

(Rac)-EGC-M5 (10 μM; 72 h) significantly increases relative ATP levels in isolated mouse splenic CD4⁺ T cells after 72 h incubation, enhancing CD4⁺ T cell activation^[1].
(Rac)-EGC-M5 (5-50 μM; 72 h) significantly upregulates PHA-induced IFN-γ production in isolated mouse splenocytes, while having no significant effect on PHA-induced IL-2 levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

Mouse spleen cells
Concentration:

10, 25 and 50 μM
Incubation Time:

72 h
Result:

Significantly upregulated the secretion of IFN-γ induced by PHA.
Was no significant change in the level of IL-2.

In Vivo

(Rac)-EGC-M5 (10 mg/kg; p.o.; daily; 14 days) increases NK cell cytotoxicity against YAC-1 cells via upregulation of granzyme B⁺ NK cells, with no significant effect on most splenic immune cell populations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (male, 8-10 weeks old)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; daily; 14 days
Result:

Increased splenic NK cell cytotoxicity against YAC-1 target cells to ~330% of control at an effector:target ratio of 20:1 and ~350% of control at an effector:target ratio of 40:1.
Increased the percentage of granzyme B+ NK cells to ~0.42%.
Showed no significant effect on populations of perforin+ NK cells, IFN-γ+ NK cells, IFN-γ+ CD8+ cells, helper T cells, cytotoxic T cells, B cells, dendritic cells, macrophages, total NK cells, Th1 cells, Th2 cells, Th17 cells, or Treg cells.

Chemical Information

CAS. Nr. 1299471-83-2
Molecular Weight 208.21
Formel C₁₁H₁₂O₄
SMILES

O=C1OC(CC1)CC2=CC(O)=CC(O)=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kim YH, et al. Green Tea Catechin Metabolites Exert Immunoregulatory Effects on CD4(+) T Cell and Natural Killer Cell Activities. J Agric Food Chem. 2016;64(18):3591-3597. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen