TTR - transthyretin Gene

Also Known as CTS; TTN; ATTR; CTS1; PALB; TBPA; HEL111; HsT2651

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7276

About TTR

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:31,591,877-31,598,821 (from NCBI)

This gene has 7 transcripts (splice variants), 177 orthologues, 1 paralogue and is associated with 6 phenotypes. Restricted expression toward liver (RPKM 2070.5).

Summary

This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid Hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in Other intracellular processes including proteolysis, nerve regeneration, Autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome. [provided by RefSeq, Aug 2017]

TTR Products (1)

mRNA	Protein	Name
NM_000371.4	NP_000362.1	transthyretin precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19861125	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	986177	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTR Protein Structure

Transthyretin

0
100
147 a.a.

Protein Preferred Names	Protein Names
transthyretin	epididymis luminal protein 111 prealbumin, amyloidosis type I thyroxine-binding prealbumin

TTR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TTR	P02766	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	TTR	P02766	OTUB1	Homo sapiens	Q96FW1	Y2H	21900206
Intra	TTR	P02766	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	TTR	P02766	AGER	Homo sapiens	Q15109	Saturation Binding	16716307
Intra	TTR	P02766	RBP4	Homo sapiens	P02753	BN-PAGE	21777382
Intra	TTR	P02766	ATF4	Homo sapiens	P18848	Y2H Array	29892012
Intra	TTR	P02766	ATF4	Homo sapiens	P18848	Y2H Array	31515488
Intra	TTR	P02766	ATF5	Homo sapiens	Q9Y2D1	Y2H Prey Pooling	32296183
Intra	TTR	P02766	ATF5	Homo sapiens	Q9Y2D1	Validated Y2H	32296183
Intra	TTR	P02766	ATF5	Homo sapiens	Q9Y2D1	Y2H Array	32296183
Intra	TTR	P02766	TTR	Homo sapiens	P02766	EM	21740906
Intra	TTR	P02766	TTR	Homo sapiens	P02766	BN-PAGE	21777382
Intra	TTR	P02766	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	SPR	18272491
Intra	TTR	P02766	TTR	Homo sapiens	P02766	Comig Non-Denat Gel	21422279
Intra	TTR	P02766	TTR	Homo sapiens	P02766	Ion Mobility Mass Spec	23850452
Intra	TTR	P02766	TTR	Homo sapiens	P02766	DLS	21740906
Intra	TTR	P02766	TTR	Homo sapiens	P02766	X-Ray Diffraction	23792159
Intra	TTR	P02766	TTR	Homo sapiens	P02766	Comigration in Gel	21740906
Intra	TTR	P02766	TTR	Homo sapiens	P02766	LM	21422279
Intra	TTR	P02766	TTR	Homo sapiens	P02766	Comig Non-Denat Gel	19861125
Intra	TTR	P02766	TTR	Homo sapiens	P02766	Fluorescence Spectr	21422279
Intra	TTR	P02766	TTR	Homo sapiens	P02766	IF	21422279
Intra	TTR	P02766	NDUFA5	Homo sapiens	Q16718	Y2H Array	32296183
Intra	TTR	P02766	NDUFA5	Homo sapiens	Q16718	Y2H Prey Pooling	32296183
Intra	TTR	P02766	NDUFA5	Homo sapiens	Q16718	Validated Y2H	32296183
Intra	TTR	P02766	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	TTR	P02766	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	TTR	P02766	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	TTR	P02766	MT3	Homo sapiens	P25713	Y2H	20646067
Intra	TTR	P02766	METTL27	Homo sapiens	Q8N6F8	Validated Y2H	32814053
Intra	TTR	P02766	METTL27	Homo sapiens	Q8N6F8	Y2H Pooling	32814053
Intra	TTR	P02766	METTL27	Homo sapiens	Q8N6F8	Y2H Array	32814053
Intra	TTR	P02766	INPP5A	Homo sapiens	Q14642	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TTR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70500	Transthyretin/TTR Protein, Human (HEK293, His)	P02766 (G21-E147)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72026	Transthyretin/TTR Protein, Human (HEK293, Fc-Myc)	P02766 (G21-E147)	≥ 90%, as determined by reducing SDS-PAGE.

TTR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81974	Prealbumin Antibody (YA1719)	WB	Rat
HY-P81974A	Prealbumin Antibody (YA1719)(PBS only)	WB	Rat
HY-P85771	Prealbumin Antibody (YA5463)	ICC/IF, WB, IHC-P	Human

Related Diseases

Diseases	Alias
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Mononeuropathy	Mononeuropathies
Mixed Cerebral Palsy	Cerebral Palsy, Mixed
Hyperthyroxinemia
Restrictive Cardiomyopathy	Familial Restrictive Cardiomyopathy Cardiomyopathy, Restrictive Cardiomyopathy, Constrictive Primary Restrictive Cardiomyopathy Rcm Cardiomyopathy Restrictive
Creutzfeldt-Jakob Disease	Variant Creutzfeldt-Jakob Disease CJD Bovine Spongiform Encephalopathy Vcjd Inherited Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Familial Creutzfeldt Jakob Disease Creutzfeldt-Jacob Disease Creutzfeldt Jacob Disease Sporadic Creutzfeldt-Jakob Disease Encephalopathy, Bovine Spongiform Creutzfeldt-Jakob Disease, Variant, Resistance To Creutzfeldt-Jakob Disease, Variant Creutzfeldt Jacob Syndrome Jakob-Creutzfeldt Disease Subacute Spongiform Encephalopathy Transmissible Virus Dementia New Variant Of Cjd Nv-Cjd Variant Cjd Variant Creutzfeldt-Jacob Disease Sporadic Cjd Inherited Cjd Acquired Creutzfeldt-Jakob Disease Variant Mcj Encephalopathy Bovine Spongiform Familial Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Syndrome New Variant Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease, Sporadic Acquired Cjd Scjd - [Sporadic Creutzfeldt-Jakob Disease] Idiopathic Creutzfeldt-Jakob Disease Creutzfeld-Jakob Disease Nos Vcjd - [Variant Creutzfeldt-Jakob Disease]
Alcoholic Neuropathy	Alcoholic Polyneuropathy Alcohol-Related Polyneuropathy Alcohol-Induced Polyneuropathy Alcoholic Peripheral Neuropathy
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Acute Porphyria	Porphyrias, Hepatic Hepatic Porphyria Porphyria Hepatic Acute Intermittent Porphyria
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Middle Ear Adenocarcinoma	Adenocarcinoma Of Middle Ear Adenocarcinoma Of The Middle Ear
Polyneuropathy	Polyneuropathies
Arteriosclerosis	Arteriosclerotic Vascular Disease
Papillary Ependymoma	Ependymoma Papillary
Hyperinsulinemic Hypoglycemia, Familial, 5	Hyperinsulinism Due To Insr Deficiency HHF5 Familial Hyperinsulinemic Hypoglycemia 5 Hyperinsulinemic Hypoglycemia Due To Insr Deficiency Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency Congenital Hyperinsulinism Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Hyperinsulinemic Hypoglycemia Familial 5
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
First-Degree Atrioventricular Block	First Degree Atrioventricular Block First Degree Heart Block Incomplete Atrioventricular Block, First Degree First Degree Atrioventricular Heart Block
Primary Cutaneous Amyloidosis	Plca Primary Localized Cutaneous Amyloidosis Familial Primary Localized Cutaneous Amyloidosis Amyloidosis Ix Lichen Amyloidosis Familial Amyloidosis, Primary Cutaneous Pca Amyloidosis 9 Amyloidosis Familial Cutaneous Lichen Fplca Familial Lichen Amyloidosis
Nutritional Deficiency Disease	Nutritional Disorder Malnutrition Nutritional Deficiency Nutrition Deficiency Diseases Carbamoyl-Phosphate Synthase I Deficiency Disease Nutrition Disorders
Carpal Tunnel Syndrome	Cts Carpal Tunnel Syndrome, Familial Carpal Tunnel Syndrome 1 CTS1 Amyotrophy, Thenar, Of Carpal Origin Carpal Tunnel Median Neuropathy Cts - Carpal Tunnel Syndrome Median Nerve Entrapment Carpal Canal Carpal Tunnel Compression Neuropathy, Carpal Tunnel Distal Median Nerve Compression Distal Median Nerve Entrapment Entrapment Neuropathy, Carpal Tunnel Median Neuropathy, Carpal Tunnel Median Neuropathy Carpal Tunnel Thenar Amyotrophy Of Crapal Origin
Decubitus Ulcer	Pressure Ulcer Pressure Sores Pressure Ulcers Bedsore Decubitus Ulcer Decubitus Ulcer Any Site
Dialysis-Related Amyloidosis	Abeta2m Amyloidosis Amyloidosis Beta2m Beta2-Microglobulinic Amyloidosis Variant Abeta2m Amyloidosis Autosomal Dominant Beta2-Microglobulinic Amyloidosis Aβ2m Amyloidosis Dialysis-Related Beta2-Microglobulin Amyloidosis Amyloidosis Dialysis-Related Beta-2-Microglobulin Amyloidosis Dra Hemodialysis-Associated Amyloidosis
Median Neuropathy
Amyloid Neuropathy	Amyloid Neuropathies Neuropathy Amyloid
Immunoglobulin Light Chain Amyloidosis	Al Amyloidosis Primary Amyloidosis Primary Systemic Amyloidosis Light Chain Amyloidosis Amyloidosis Al Amyloidosis Primary Systemic Primary Al Amyloidosis Primary Systemic Al Amyloidosis Systemic Al Amyloidsis Systemic Al Amyloidosis Light-Chain Amyloidosis Alys Amyloidosis Familial Amyloid Nephropathy Due To Lysozyme Variant Familial Renal Amyloidosis Due To Lysozyme Variant Hereditary Amyloid Nephropathy Due To Lysozyme Variant Hereditary Renal Amyloidosis Due To Lysozyme Variant Lysozyme Amyloidosis Amyloidosis Primary Immunoglobulin Deposition Disease Immunoglobulinic Amyloidosis Amyloid Al
Amyloid Tumor	Amyloid Neoplasm Amyloid Tumour
Phenylketonuria	Phenylalanine Hydroxylase Deficiency PKU Pah Deficiency Folling Disease Maternal Phenylketonuria Phenylketonurias Oligophrenia Phenylpyruvica Hyperphenylalaninemia, Non-Pku Mild Folling'S Disease Phenylalaninemia Mild Phenylketonuria Mild Pku Variant Pku Variant Phenylketonuria Mpku Phenylketonuria, Maternal Deficiency Disease, Phenylalanine Hydroxylase Phenylalanine Hydroxylase Deficiency Disease Hyperphenylalaninemic Embryopathy Maternal Pku Maternal Hyperphenylalaninemia Phenylketonuric Embryopathy Hyperphenylalaninemia HPA Non-Phenylketonuria Hyperphenylalaninemia NON-PKU HPA Phenylketonuria Maternal Classical Phenylketonuria Hyperphenylalaninaemia Pku - [Phenylketonuria]
Obstructive Jaundice	Jaundice, Obstructive Cholestatic Jaundice Cholestatic Jaundice Syndrome Obstructive Hyperbilirubinemia Jaundice Obstructive Jaundice Cholestatic
Analbuminemia	ANALBA Congenital Analbuminemia Hypoalbuminemia
Pulmonary Coin Lesion	Coin Lesion Of Lung Solitary Pulmonary Nodule Coin Lesion Lung
Chronic Inflammatory Demyelinating Polyradiculoneuropathy	Chronic Inflammatory Demyelinating Polyneuropathy Cidp Polyradiculoneuropathy Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Hereditary Amyloidosis	Amyloidosis Hereditary Familial Amyloidosis Amyloidosis Familial Amyloidosis, Hereditary Amyloidosis, Familial Genetic Amyloidosis Heredofamilial Amyloidosis
Immunoglobulin Heavy Chain Amyloidosis	Ah Amyloidosis Heavy Chain Amyloidosis Amyloidosis Derived From Immunoglobulin Heavy Chain Ig Heavy-Chain-Associated Amyloidosis
Gerstmann-Straussler Disease	Gerstmann-Straussler-Scheinker Disease Gerstmann-Straussler-Scheinker Syndrome Prion Dementia Cerebral Amyloid Angiopathy, Prnp-Related GSD Gss Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In Cns Amyloidosis, Cerebral, With Spongiform Encephalopathy Subacute Spongiform Encephalopathy, Gerstmann-Straussler Type Encephalopathy, Subacute Spongiform, Gerstmann-Straussler Type Amyloidosis Cerebral With Spongiform Encephalopathy Cerebellar Ataxia, Progressive Dementia, And Amyloid Deposits In The Central Nervous System Encephalopathy Subacute Spongiform Gerstmann-Straussler Type Gssd Gerstmann Straussler Scheinker Syndrome Cerebral Amyloidosis With Spongiform Encephalopathy Subacute Spongiform Encephalopathy Gerstmann-Straussler Type Gluthathione Synthetase Deficiency Gerstmann Straussler Syndrome
Amyloidosis, Finnish Type	Finnish Type Amyloidosis Meretoja Syndrome Amyloidosis V Amyloidosis, Meretoja Type Amyloid Cranial Neuropathy With Lattice Corneal Dystrophy Lattice Corneal Dystrophy Type Ii Familial Amyloid Polyneuropathy Type Iv Amyloidosis Due To Mutant Gelsolin Agel Amyloidosis Gelsolin Amyloidosis Familial Amyloidosis, Finnish Type Hereditary Gelsolin Amyloidosis Lattice Corneal Dystrophy Type Ii Finnish Gelsolin-Related Amyloidosis Kymenlaakso Syndrome Lattice Corneal Dystrophy, Gelsolin Type Hereditary Amyloidosis, Finnish Type Lattice Corneal Dystrophy Type 2 Amyloidosis 5 AMYL5 Agel Familial Amyloidosis Finnish Type Meretoja Type Amyloidosis Type Iv Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy, Type V Familial Amyloid Polyneuropathy, Type Iv
Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a	Multiple Pterygium Syndrome, Autosomal Dominant CPSFS1A Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a Autosomal Dominant Disease Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a Cpskf1a Pterygium Syndrome, Multiple Autosomal Dominant Arthrogryposis, Distal, Type 8, Formerly Da8, Formerly Autosomal Dominant Multiple Pterygium Syndrome Distal Arthrogryposis Type 8 Arthrogryposis, Distal, Type 8 Da8 Pterygium Syndrome, Multiple, Autosomal Dominant Autosomal Dominant Disorder
Chronic Ulcer Of Skin	Chronic Wounds Callous Ulcer Indolent Ulcer Chronic Ulcer
Amyloidosis	Amyloid Disease Amyloid Amyloid Degeneration Amyloidosis Nos Amyloid Deposition Amyloid Infiltration Idiopathic Amyloidosis Hyaloid Degeneration Lardaceous Degeneration
Carotenemia	Hypercarotinemia
Hypothyroidism	Thyroid Diseases Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Disease Thyroid Dysfunction
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Middle Ear Carcinoma	Carcinoma Of Middle Ear Carcinoma Of The Middle Ear
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Inclusion Body Myositis	Ibm Sporadic Inclusion Body Myositis Myositis, Inclusion Body Inflammatory Myopathy Inflammatory Myopathies Sibm Myositis Inclusion Body Nonaka Myopathy Inclusion Body Myopathy, Autosomal Recessive Inclusion Body Myopathy, Autosomal Dominant Myositis Inclusion Body Myopathy, Sporadic
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Euthyroid Dysprealbuminemic Hyperthyroxinemia	Euthyroid Dystransthyretinemic Hyperthyroxinemia
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Hyperhomocysteinemia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Eunuchism
Diastolic Heart Failure	Heart Failure, Diastolic
Conjunctival Deposit
Amyloidosis, Hereditary, Transthyretin-Related	Transthyretin Amyloidosis Familial Amyloid Polyneuropathy Ttr Amyloid Neuropathy Transthyretin Amyloid Neuropathy Transthyretin Amyloid Polyneuropathy Fap Familial Transthyretin Amyloidosis Amyloidosis Transthyretin Related Type I Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy Type I Attrv122i Amyloidosis Hereditary Amyloidosis, Transthyretin-Related Amyloid Polyneuropathy, Familial Attr Amyloidosis Attrm Amyloidosis Corino De Andrade'S Disease Paramyloidosis Transthyretin-Related Hereditary Amyloidosis Ttr Amyloidosis Hereditary Attr Amyloidosis Portuguese Polyneuritic Amyloidosis Portuguese Type Familial Amyloid Neuropathy Swiss Type Amyloid Polyneuropathy Type Ii Familial Amyloid Polyneuropathy Attrv30m Amyloidosis Attrv30m-Related Amyloidosis Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type Attr Cardiomyopathy Attrv122i-Related Amyloidosis Ttr-Related Amyloid Cardiomyopathy Ttr-Related Cardiac Amyloidosis Transthyretin Amyloid Cardiopathy Transthyretin-Related Familial Amyloid Cardiomyopathy Amyloidosis, Transthyretin-Related AMYL-TTR Amyloidosis I Amyloidosis Ohio Type Amyloidosis Type 7 Amyloidosis Vii Amyloid Polyneuropathy Attr Familial Amyloid Polyneuropathy Type Ii Hereditary Amyloidosis Transthyretin-Related Leptomeningeal Amyloidosis Meningocerebrovascular Amyloidosis Oculoleptomeningeal Amyloidosis Familial Amyloid Polyneuropathies Amyloidosis, Leptomeningeal Senile Cardiac Amyloidosis Amyloid Neuropathies, Familial Danish Type Familial Amyloid Cardiomyopathy Familial Amyloid Neuropathy, Portuguese Type Amyloid Polyneuropathy, Swiss Type Hereditary Oculoleptomeningeal Amyloid Angiopathy Amyloid Neuropathies
Autonomic Peripheral Neuropathy	Peripheral Autonomic Nervous System Diseases
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Pure Autonomic Failure	Orthostatic Hypotension Idiopathic Orthostatic Hypotension Postural Hypotension Bradbury-Eggleston Syndrome Bradbury Eggleston Syndrome Hypotension, Orthostatic Hypotension, Postural Paf Pure Dysautonomia Pure Idiopatic Dysautonomia Hypotension Orthostatic Primary Orthostatic Hypotension Chronic Orthostatic Hypotension
Asymmetric Motor Neuropathy
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Familial Renal Amyloidosis Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Heart Valve Disease	Heart Valve Diseases Valvular Heart Disease Valvular Heart Diseases Heart Valve Prolapse
Papilloma Of Choroid Plexus	Choroid Plexus Papilloma CPP Childhood Choroid Plexus Papilloma Papilloma Choroid Plexus Papilloma, Choroid Plexus Choroid Plexus Carcinoma
Diabetes Mellitus	Diabetes
Hepatic Encephalopathy	Encephalopathy, Hepatic Portal-Systemic Encephalopathy Hepatoencephalopathy He - [Hepatic Encephalopathy] Hepatic Encephalopathy Nos Hepatic Encephalopathy, Stage Unspecified Hepatic Coma Hepatocerebral Encephalopathy Hepatocerebral Intoxication
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Liver Cirrhosis	Cirrhosis Cirrhosis Of Liver CIRRH Cryptogenic Cirrhosis Cirrhosis, Cryptogenic Cirrhosis Nos
Pericardial Effusion	Noninflammatory Pericardial Effusion Pericardium Effusion
Protein-Losing Enteropathy	Protein-Losing Enteropathies Enteropathy, Exudative Exudative Enteropathy Ple - [Protein-Losing Enteropathy]
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Aortic Valve Disease 2	Aortic Valve Stenosis Aortic Stenosis Rheumatic Aortic Stenosis AOVD2 Bicuspid Aortic Valve Rheumatic Aortic Valve Stenosis Valvular Aortic Stenosis Aortic Valve Disease, Type 2 Aortic Valve Stricture Aortic Valve Obstruction Obstructed Aorta Valve Rheumatic Aortic Obstruction Rheumatic Aortic Valve Obstruction Rheumatic Aortic Stricture Aortic Valve Regurgitation Aortic Insufficiency With Stenosis Rheumatic Aortic Valve Stenosis With Insufficiency Rheumatic Aortic Stenosis With Incompetence Rheumatic Aortic Stenosis With Regurgitation
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Nerve Compression Syndrome	Entrapment Neuropathies Compression Neuropathy Entrapment Neuropathy Peripheral Nerve Entrapment Syndrome Nerve Compression Syndromes Hereditary Liability To Pressure Palsies
Pineal Region Choriocarcinoma	Pineal Choriocarcinoma
Autosomal Genetic Disease	Autosomal Hereditary Disorder
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Mitral Valve Stenosis	Mitral Stenosis Rheumatic Mitral Stenosis Ms - [Mitral Stenosis] Mitral Valvular Stricture Mitral Valve Stricture Mitral Stricture Chronic Mitral Stenosis Mitral Obstruction Mitral Valve Obstruction Mitral Stenosis With Incompetence Mitral Stenosis With Regurgitation Rheumatic Mitral Insufficiency With Obstruction
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Choroid Plexus Cancer	Choroid Plexus Carcinoma Choroid Plexus Neoplasms Choroid Plexus Neoplasm Tumor Of Choroid Plexus Tumor Of The Choroid Plexus Choroid Plexus Tumor Choroid Plexus Tumors Anaplastic Choroid Plexus Papilloma Choroid Plexus Papilloma Nos Papilloma Of Choroid Plexus Plexus Choroideus Papilloma Choroid Plexus Papilloma In Fourth Ventricle Plexus Choroideus Papilloma In Fourth Ventricle
Wild-Type Amyloidosis	Senile Systemic Amyloidosis Attrwt Amyloidosis Age Related Amyloidosis Old Age Amyloidosis Wild-Type Attr Amyloidosis Wild-Type Transthyretin Cardiac Amyloidosis Wild Type Attr Amyloidosis Attrwt-Related Amyloidosis Wild Type Attr-Related Amyloidosis
Dysentery	Infectious Diarrhea
Short Bowel Syndrome	Short Gut Syndrome Acquired Short Bowel Syndrome Secondary Short Bowel Syndrome Short Bowel Nos
Alopecia-Mental Retardation Syndrome 1	APMR1 Alopecia-Intellectual Disability Syndrome 1 Amr Syndrome Alopecia-Intellectual Disability Syndrome Amr Syndrome 1 Alopecia With Severe Intellectual Deficit Apmr Alopecia Intellectual Disbility Syndrome 1 Perniola-Krajewska-Carnevale Syndrome Alopecia - Intellectual Disability Syndrome Alopecia With Mental Retardation Syndrome 1 Perniola Krajewska Carnevale Syndrome
Protein-Energy Malnutrition	PEM Protein Energy Malnutrition
Iron Metabolism Disease	Iron Deficiency Iron Disorder Iron Metabolism Disorders Disorder Of Iron Metabolism Iron Fe Deficiency Iron Storage Disease Iron Storage Disorder
Hypervitaminosis A	Hypervitaminosis A, Susceptibility To Hyperalimentation Of Vitamin A
Marasmus	Nutritional Marasmus Nutritional Atrophy
Mitral Valve Disease	Chronic Rheumatic Mitral Valve Rheumatic Mitral Insufficiency Disease Of Mitral Valve Mitral Rh Valve Dis. Rheumatic Disease Of Mitral Valve Rheumatic Mitral Valve Changes Rheumatic Mitral Valve Incompetence Rheumatic Mitral Valve Regurgitation Abnormality Of The Mitral Valve Diseases Of Mitral Valve Rheumatic Mitral Regurgitation
Atrial Standstill 1	ATRST1 Atrial Cardiomyopathy With Heart Block Cardiomyopathy, Familial, With Conduction Disturbance Atrial Standstill, Digenic Familial Cardiomyopathy With Conduction Disturbance Standstill, Atrial, Type 1 Heart Block Cardiomyopathies Idiopathic Cardiomyopathy Idiopathic Cardiopathy Primary Myocardial Disease Primary Cardiomyopathy Myocardiopathy Myocardosis Primary Idiopathic Myocardial Disease
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Molybdenum Cofactor Deficiency	Combined Molybdoflavoprotein Enzyme Deficiency Mocod Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase, And Aldehyde Oxidase Combined Deficiency Of Sulfite Oxidase, Xanthine Dehydrogenase And Aldehyde Oxidase Combined Xanthine Oxidase And Sulfite Oxidase And Aldehyde Oxidase Deficiency Deficiency Of Molybdenum Cofactor Deficiency, Molybdenum Cofactor
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Keratomalacia	Vitamin A Deficiency Night Blindness Retinol Deficiency Xerotic Keratitis VAD Vitamin A Hypovitaminosis A Bitot Spots Bitot Spots In The Young Child Conjunctival Xerosis With Bitot'S Spots Vitamin A Deficiency With Cornea Xerosis Vitamin A Deficiency With Cornea Ulceration Or Xerosis
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Epicardium Cancer	Malignant Neoplasm Of Epicardium Epicardial Tumor Malignant Epicardial Tumor Neoplasm Of Epicardium
Cerebral Amyloid Angiopathy, Cst3-Related	Cerebral Amyloid Angiopathy Hereditary Cerebral Hemorrhage With Amyloidosis Hchwa Cerebral Amyloid Angiopathy, Familial Hereditary Cystatin C Amyloid Angiopathy Amyloidosis, Cerebroarterial, Icelandic Type Amyloidosis Vi Cerebral Hemorrhage, Hereditary, With Amyloidosis Cst3-Related Cerebral Amyloid Angiopathy Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant Caa, Familial Cerebral Amyloid Angiopathy, Genetic Acys Amyloidosis Cst3-Related Amyloidosis Cystatin Amyloidosis Hchwa, Icelandic Type Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type Amyloidosis 6 AMYL6 Acys Caa Cerebral Amyloid Angiopathy Cst3-Related Cerebroarterial Amyloidosis Icelandic Type Cystatin C Amyloidosis Hccaa Hchwai Hchwa-I Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type Cerebral Amyloid Angiopathy Familial Angiopathy, Amyloid, Cerebral, Cst3-Related Hereditary Cerebral Amyloid Angiopathy, Icelandic Type Familial Cerebral Amyloid Angiopathy Cerebral Amyloid Angiopathy, Hereditary
Endocarditis
Demyelinating Polyneuropathy	Peripheral Demyelinating Neuropathy Demyelinating Peripheral Neuropathy
Blepharochalasis	Dermatolysis Palpebrarum Adiposa Ptosis
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Cerebrovascular Benign Neoplasm
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Intraocular Pressure Quantitative Trait Locus	Glaucoma IOPQTL Glaucoma, Susceptibility To Postinfectious Glaucoma Glaucoma With Ocular Inflammation Glaucoma Secondary To Eye Inflammation Traumatic Glaucoma Glaucoma With Concussion Of Globe Glaucoma Due To Ocular Trauma Glaucoma Associated With Ocular Trauma Glaucoma Secondary To Drugs
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Pericardium Disease
Serum Amyloid A Amyloidosis	Aa Amyloidosis Secondary Amyloidosis Reactive Systemic Amyloidosis Apo Serum Amyloid A Amyloidosis Inflammation Aa Amyloidosis Amyloidosis Aa Amyloid A Amyloidosis Inflammatory Amyloidosis Reactive Amyloidosis Amyloidosis Secondary Secondary Systemic Amyloidosis Amyloid Aa
Suppurative Uveitis	Uveitis, Suppurative
Cardiac Sarcoidosis
Barth Syndrome	3-Methylglutaconic Aciduria Type 2 BTHS Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria Mga Type Ii Mga2 Mgca2 Mga Type 2 3-Methylglutaconic Aciduria Type Ii 3-Methylglutaconic Aciduria, Type Ii Mga, Type Ii 3-Methylglutaconicaciduria Type 2 3-Methylglutaconicaciduria Type Ii Taz Defect 3 Methylglutaconic Aciduria, Type Ii Dnajc19 Defect Cardioskeletal Myopathy-Neutropenia Syndrome X-Linked Cardioskeletal Myopathy And Neutropenia 3-Alpha-Methylglutaconic Aciduria Type 2 Agm2 Cardioskeletal Myopathy-Neutropenia Invm Left Ventricular Non-Compaction Isolated X-Linked Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked Agammaglobulinemia 2, Autosomal Recessive
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Hypertensive Heart Disease
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic, Familial Familial Hypertrophic Cardiomyopathy Cardiomyopathy Hypertrophic Obstructive Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Cataract 7	Cca1 CTRCT7 Cerulean Cataract Cataract 7, Cerulean Type Cataract, Congenital, Cerulean Type, 1 Cerulean Type Cataract 7 Congenital Cerulean Type Cataract 1 Cataract, Congenital, Blue Dot Type 1 Cataract, Congenital, Cerulean Type 1 Blue-Dot Cataract
Scoliosis
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Pancytopenia
Hyperthyroxinemia, Dystransthyretinemic	Dystransthyretinemic Euthyroidal Hyperthyroxinemia Dystransthyretinemic Hyperthyroxinemia DTTRH Euthryroidal Hyperthyroxinemia 2 Hyperthyroxinemia, Dysprealbuminemic Hyperthyroxinemia Dysprealbuminemic Hyperthyroxinemia Dystransthyretinemic Hyperthyroxinemia, Euthyroidal, Dystransthyretinemic
Paralytic Lagophthalmos
Central Nervous System Disease	CNS Cns Diseases Central Nervous System Diseases Cns Disorder
Kwashiorkor	Kwashiokor Nutritional Edema With Dyspigmentation Of Skin And Hair Nutritional Oedema With Dyspigmentation Of Skin And/Or Hair
Constrictive Pericarditis	Pericarditis, Constrictive Pericarditis Constrictive Pericarditis Calculosa Hutinel-Pick Syndrome Chronic Tamponade Chronic Pericardial Constriction Pick Syndrome Of Heart Pick Disease Of Heart Concretio Cordis Calcareous Pericarditis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132609	Patisiran sodium		99.09%	Unkown
HY-14852	Tafamidis	Inhibitor	99.93%	Yes
HY-132608	Inotersen sodium		96.44%	Unkown
HY-132589	Vutrisiran		97.37%	Unkown
HY-132589A	Vutrisiran sodium	Inhibitor	97.37%	Unkown
HY-14852A	Tafamidis meglumine		99.79%	Yes
HY-148089A	Eplontersen sodium	Inhibitor	96.95%	Unkown
HY-112974	Inotersen	Inhibitor	96.44%	Unkown
HY-148089	Eplontersen	Inhibitor	98.70%	Unkown
HY-14852R	Tafamidis (Standard)	Inhibitor	99.24%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109165	Acoramidis		98.47%	Phase 3
HY-109165A	Acoramidis hydrochloride		98.70%	Phase 3
HY-177650	Nucresiran	Inhibitor	97.24%	Phase 1
HY-177650A	Nucresiran sodium	Inhibitor	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990734	Coramitug	Inhibitor	99.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N1957	Gamma-Mangostin		99.91%	Unkown
HY-113283	Homogentisic acid		99.68%	Unkown
HY-132590A	Revusiran sodium	Inhibitor	93.16%	Unkown
HY-153609	AS-Patisiran sodium	Inhibitor	95.10%	Unkown
HY-W331198	Tralopyril	Inducer	99.70%	Unkown
HY-113950	Dichlorophenyl-ABA		99.79%	Unkown
HY-153577	WT-TTR inhibitor 1	Inhibitor	98.03%	Unkown
HY-RS15238	TTR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-165604	C14-490		98%	Unkown
HY-185504	Nexiguran		/	Unkown
HY-132590	Revusiran		/	Unkown
HY-146137	Transthyretin-IN-1		/	Unkown
HY-147366	RBP4 ligand-1	Inhibitor	/	Unkown
HY-14852S	Tafamidis-d3		/	Unkown
HY-155299	PITB	Inhibitor	/	Unkown
HY-159658	TTR stabilizer 1	Modulator	/	Unkown
HY-161505	Transthyretin-IN-3	Inhibitor	/	Unkown
HY-P10615	Abz-YGGRASDQ-EDDnp		/	Unkown
HY-P11698	Guanidino-G-Clamp-PNA	Inhibitor	/	Unkown
HY-RS15239	Ttr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15240	Ttr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-126927	TTR stabilizer L6	Modulator	/	Unkown
HY-160612	Transthyretin-IN-2	Inhibitor	/	Unkown
HY-176233	Transthyretin-IN-4	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991128	Cliramitug		97.0%	Unkown
HY-P991412	NI-301	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TTR	VGNC	VGNC:47983
Bos taurus	TTR	VGNC	VGNC:36499
Rattus norvegicus	TTR	RGD	RGD:3916
Felis catus	TTR	VGNC	VGNC:66693
Mus musculus	TTR	MGD	MGI:98865
Macaca mulatta	TTR	VGNC	VGNC:78671
Others	TTR	NCBI