Cliramitug (Synonyms: NI-006; ALXN2220)

Cat. No.: HY-P991128 Purity: 97.0%: Data Sheet
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Cliramitug (NI-006; ALXN2220) is a monoclonal antibody that targets human transthyretin (TTR). Cliramitug binds to TTR and inhibits its amyloidogenic process, exerting amyloid formation-inhibiting activity. Cliramitug can be used in the research of transthyretin amyloidosis-related diseases, such as certain neurological and cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No. : 2965214-50-8

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
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Description	Cliramitug (NI-006; ALXN2220) is a monoclonal antibody that targets human transthyretin (TTR). Cliramitug binds to TTR and inhibits its amyloidogenic process, exerting amyloid formation-inhibiting activity. Cliramitug can be used in the research of transthyretin amyloidosis-related diseases, such as certain neurological and cardiovascular diseases^[1].
Isotype	Human IgG1 kappa
Recommend Isotype Controls	Human IgG1 kappa, Isotype Control
Species Reactivity	Human
IC₅₀ & Target	Transthyretin/TTR
In Vitro	Cliramitug accelerates phagocyte-mediated clearance of dense-structured ATTR amyloid fibrils in vitro^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cliramitug Related Antibodies
Gene ID	7276 [NCBI]
Accession	P02766
Application	ELISA, FACS, Functional assay
Conjugated	Unconjugated
Reconsititution	The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight	144.542 kDa
CAS No.	2965214-50-8
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Cliramitug]
Shipping	Shipping with dry ice.
Formulation	Please refer to the lot-specific COA for specific buffer information.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Format	IgG1-kappa
Purity & Documentation	Purity: 97.0% Select Batch: Data Sheet (255 KB) SDS (251 KB) COA (232 KB) SDS-PAGE (139 KB) SEC-HPLC (192 KB) Inhibitory Antibodies User Guide (603 KB)
References	[1]. Pillai AA, et al. Antibody ALXN2220 (Formerly NI006) for the Treatment of Transthyretin Cardiac Amyloidosis. Cardiol Rev. Published online April 22, 2025. [Content Brief]

Cliramitug Related Classifications

Neurological Disease Cardiovascular Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Cliramitug (Synonyms: NI-006; ALXN2220)

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