PCGF5 - polycomb group ring finger 5 Gene

Also Known as RNF159

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84333

About PCGF5

Cytogenetic location: 10q23.32 Genomic coordinates (GRCh38): 10:91,156,219-91,284,337 (from NCBI)

This gene has 5 transcripts (splice variants), 211 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), adrenal (RPKM 12.4) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in Golgi apparatus; centrosome; and nucleoplasm. Part of PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

PCGF5 Products (3)

mRNA Protein Name
NM_001256549.2 NP_001243478.1 polycomb group RING finger protein 5
NM_001257101.2 NP_001244030.1 polycomb group RING finger protein 5
NM_032373.5 NP_115749.2 polycomb group RING finger protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19273555 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25519132 GOA
Cellular Component GO Annotation Evidence References Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
21282530 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21282530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCGF5 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 56)

  • 0
  • 100
  • 200
  • 256 a.a.
Protein Preferred Names Protein Names

polycomb group RING finger protein 5

  • RING finger protein 159

PCGF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PCGF5 Q86SE9 BCOR Homo sapiens Q6W2J9-4
Y2H Array
25416956
Intra
PCGF5 Q86SE9 BCOR Homo sapiens Q6W2J9-4
Y2H Prey Pooling
25416956
Cross
PCGF5 Q86SE9 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Anti Tag CoIP
19273555
Cross
PCGF5 Q86SE9 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Confocal
19273555
Intra
PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
Anti Tag CoIP
33961781
Intra
PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
TAP
27705803
Intra
PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
Anti Tag CoIP
28514442
Intra
PCGF5 Q86SE9 AUTS2 Homo sapiens Q8WXX7
Anti Tag CoIP
25519132
Intra
PCGF5 Q86SE9 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra
PCGF5 Q86SE9 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
PCGF5 Q86SE9 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
PCGF5 Q86SE9 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
Intra
PCGF5 Q86SE9 PHC2 Homo sapiens Q8IXK0
Validated Y2H
25416956
Intra
PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra
PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
25519132
Intra
PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
22493164
Intra
PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Y2H Array
22493164
Intra
PCGF5 Q86SE9 RNF2 Homo sapiens Q99496
Anti Tag CoIP
28514442
Intra
PCGF5 Q86SE9 RING1 Homo sapiens Q06587
Anti Tag CoIP
22493164
Intra
PCGF5 Q86SE9 RING1 Homo sapiens Q06587
TAP
27705803
Intra
PCGF5 Q86SE9 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra
PCGF5 Q86SE9 RING1 Homo sapiens Q06587
Y2H Array
22493164
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bainbridge-Ropers Syndrome

  • BRPS

  • Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome

  • Asxl3-Related Disorder
Ehrlichiosis

  • Human Ehrlichiosis

  • He

  • Hey
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10148 PCGF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PCGF5 VGNC VGNC:44303
Macaca mulatta PCGF5 VGNC VGNC:106085
Rattus norvegicus PCGF5 RGD RGD:1583513
Mus musculus PCGF5 MGD MGI:1923505
Bos taurus PCGF5 VGNC VGNC:32628
Others PCGF5 NCBI