Pittsburgh Compound B
Based on 1 Customer Validation
Pittsburgh Compound B (PiB) is a blood-brain barrier-permeable, specific Aβ deposition PET tracer that binds to Aβ(1-40) fibrils with a Ki value of 678.4 nM. Through click chemical modification (a clickable Pittsburgh Compound B derivative is prepared by introducing a PEG3 linker and an alkynyl group at the 6-hydroxy site of Pittsburgh Compound B, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC)), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and enrichment and characterization of Aβ complexes. Pittsburgh Compound B is applicable to Alzheimer's disease research.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 566169-93-5
- Formula: C14H12N2OS
- Molecular Weight:256.33
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Pittsburgh Compound B binds synthetic Aβ(1-40) fibrils with a Ki of 678.4 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 566169-93-5
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Appearance Solid
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Molecular Weight 256.33
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Formula C14H12N2OS
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Color Light yellow to yellow
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SMILES
OC1=CC=C2N=C(SC2=C1)C3=CC=C(C=C3)NC
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Synonyms
PiB; 6-OH-BTA-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (195.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Diner I, et al. Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain. Bioconjug Chem. 2017;28(10):2627-2637. [Content Brief]
[2]. Rosen RF, et al. Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease. Acta Neuropathol. 2010;119(2):221-233. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9012 mL | 19.5061 mL | 39.0122 mL | 97.5305 mL |
| 5 mM | 0.7802 mL | 3.9012 mL | 7.8024 mL | 19.5061 mL | |
| 10 mM | 0.3901 mL | 1.9506 mL | 3.9012 mL | 9.7531 mL | |
| 15 mM | 0.2601 mL | 1.3004 mL | 2.6008 mL | 6.5020 mL | |
| 20 mM | 0.1951 mL | 0.9753 mL | 1.9506 mL | 4.8765 mL | |
| 25 mM | 0.1560 mL | 0.7802 mL | 1.5605 mL | 3.9012 mL | |
| 30 mM | 0.1300 mL | 0.6502 mL | 1.3004 mL | 3.2510 mL | |
| 40 mM | 0.0975 mL | 0.4877 mL | 0.9753 mL | 2.4383 mL | |
| 50 mM | 0.0780 mL | 0.3901 mL | 0.7802 mL | 1.9506 mL | |
| 60 mM | 0.0650 mL | 0.3251 mL | 0.6502 mL | 1.6255 mL | |
| 80 mM | 0.0488 mL | 0.2438 mL | 0.4877 mL | 1.2191 mL | |
| 100 mM | 0.0390 mL | 0.1951 mL | 0.3901 mL | 0.9753 mL |
Pittsburgh Compound B Related Classifications
HY-126192 Related Classifications
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- Pittsburgh Compound B
- 566169-93-5
- PiB
- 6-OH-BTA-1
- Amyloid-β
- Ligands for Target Protein for PROTAC
- α-synuclein
- positron emission tomography (PET)
- β-amyloid (Aβ)
- temporal cortical homogenates
- aggregated amyloid beta (Aβ)
- blood-brain barrier
- Alzheimer's disease (AD)
- Aβ deposits
- Aβ(1-40) fibrils
- non-AD phenotype animal models
- occipital cortical homogenates
- Inhibitor
- inhibitor
- inhibit