1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Denopamine

Denopamine (Synonyms: (R)-(-)-Denopamine; TA-064)

Cat. No.: HY-119515
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Denopamine ((R)-(-)-Denopamine) is an orally active, selective β1-adrenergic agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects.

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Denopamine Chemical Structure

Denopamine Chemical Structure

CAS No. : 71771-90-9

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Description

Denopamine ((R)-(-)-Denopamine) is an orally active, selective β1-adrenergic agonist. Denopamine prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-α production in the heart. Cardiovascular effects[1].

In Vitro

Denopamine (0.1-100 μM) suppresses LPS-induced TNF-α production in a concentration-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Murine spleen cells
Concentration: 0, 0.1, 1, 10, 100 μM
Incubation Time: 5 hours
Result: Decreased TNF-α levels by 96.9±6.7%, 62.7±6.5%, 53.2±8.8%, and 40.3±1.5% at 0.1, 1, 10 and 100 μmol/L, respectively.
In Vivo

Denopamine (14 μmol/kg per day; oral administration; for 14 days) significantly improves the survival of the animals, attenuates myocardial lesions, and suppresses TNF-α production in vivo[1].
The plasma concentration of Denopamine is 13.1±1.9 nmol/L at 1 h, 4.3±0.9 nmol/L at 2 h, 1.8±0.5 nmol/L at 3 h, and <0.6 nmol/L at 5 h after its administration. A single 14 μmol/kg dose of denopamine in mice produces a peak level at 1 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old inbred male DBA/2 mice[1]
Dosage: 14 μmol/kg per day
Administration: Oral administration; 14 days
Result: Treatment significantly improved the survival of the animals (14 of 25 (56%) treated, vs 5 of 25 (20%) control mice).
At day 14, the survival rate of 57.1% (16 of 28 mice) in the treated group was significantly higher than the 33.3% (10 of 30 mice) survival rate in the control group.
The survival rate from day 6 to day 14 was also significantly improved in the treated group (69.6%; 16 of 23 mice) versus the control group (45.5%; 10 of 22 mice, p < 0.05).
Molecular Weight

317.38

Formula

C₁₈H₂₃NO₄

CAS No.
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Denopamine
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HY-119515
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