CBX6 - chromobox 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23466

About CBX6

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,861,422-38,872,216 (from NCBI)

This gene has 3 transcripts (splice variants), 109 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 28.2), ovary (RPKM 14.0) and 24 other tissues.

Summary

Predicted to enable single-stranded RNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Biomarker of glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX6 Products (2)

mRNA Protein Name
NM_001303494.2 NP_001290423.1 chromobox protein homolog 6 isoform 2
NM_014292.5 NP_055107.3 chromobox protein homolog 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18927235 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
21282530 GOA
Cellular Component GO Annotation Evidence References Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
21282530 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21282530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX6 Protein Structure

Chromo

Chromo: Chromo (CHRromatin Organisation MOdifier) domain (13 - 60)

  • 0
  • 100
  • 200
  • 300
  • 412 a.a.
Protein Preferred Names Protein Names

chromobox protein homolog 6

  • chromobox homolog 6

CBX6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CBX6 O95503 MOV10 Homo sapiens Q9HCE1
TAP
21282530
Intra
CBX6 O95503 MOV10 Homo sapiens Q9HCE1
Anti Tag CoIP
33961781
Intra
CBX6 O95503 PCGF2 Homo sapiens P35227
Pull Down
21282530
Intra
CBX6 O95503 PCGF3 Homo sapiens Q3KNV8
Anti Tag CoIP
21282530
Intra
CBX6 O95503 BMI1 Homo sapiens P35226
TAP
27705803
Intra
CBX6 O95503 BMI1 Homo sapiens P35226
TAP
24981860
Intra
CBX6 O95503 BMI1 Homo sapiens P35226
Anti Tag CoIP
33961781
Intra
CBX6 O95503 BMI1 Homo sapiens P35226
Anti Tag CoIP
21282530
Intra
CBX6 O95503 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
CBX6 O95503 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra
CBX6 O95503 RNF2 Homo sapiens Q99496
TAP
21282530
Intra
CBX6 O95503 RNF2 Homo sapiens Q99496
TAP
24981860
Intra
CBX6 O95503 PCGF1 Homo sapiens Q9BSM1
Anti Tag CoIP
33961781
Intra
CBX6 O95503 RING1 Homo sapiens Q06587
TAP
27705803
Intra
CBX6 O95503 RING1 Homo sapiens Q06587
Pull Down
21282530
Intra
CBX6 O95503 RING1 Homo sapiens Q06587
Anti Tag CoIP
21282530
Intra
CBX6 O95503 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra
CBX6 O95503 RING1 Homo sapiens Q06587
TAP
21282530
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Benign Pleural Mesothelioma

  • Mesothelioma Of Pleura

  • Benign Neoplasm Of Mesothelial Tissue Of Pleura

  • Pleural Malignant Mesothelioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181089 CBX2-IN-1 Inhibitor / Unkown
HY-RS02013 CBX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21303 Cbx6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27822 Cbx6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CBX6 MGD MGI:3512628
Bos taurus CBX6 VGNC VGNC:26819
Rattus norvegicus CBX6 RGD RGD:1307314
Others CBX6 NCBI