MOV10 - Mov10 RISC complex RNA helicase Gene

Also Known as gb110; fSAP113

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4343

About MOV10

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,674,439-112,700,739 (from NCBI)

This gene has 26 transcripts (splice variants), 295 orthologues and 10 paralogues. Ubiquitous expression in placenta (RPKM 19.5), small intestine (RPKM 18.6) and 25 other tissues.

Summary

Enables 5'-3' RNA helicase activity and RNA binding activity. Involved in defense response to virus; negative regulation of transposition, RNA-mediated; and posttranscriptional regulation of gene expression. Located in P-body and cytosol. Implicated in hypertension. [provided by Alliance of Genome Resources, Apr 2022]

MOV10 Products (7)

mRNA	Protein	Name
NM_001130079.3	NP_001123551.1	helicase MOV-10 isoform 1
NM_001286072.2	NP_001273001.1	helicase MOV-10 isoform 2
NM_001321324.2	NP_001308253.1	helicase MOV-10 isoform 1
NM_001369507.1	NP_001356436.1	helicase MOV-10 isoform 1
NM_001389562.1	NP_001376491.1	helicase MOV-10 isoform 2
NM_001389563.1	NP_001376492.1	helicase MOV-10 isoform 2
NM_020963.5	NP_066014.1	helicase MOV-10 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 5'-3' RNA helicase activity	IDA IDA: Inferred from direct assay	24726324	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	23093941	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16289642	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-UTR-mediated mRNA destabilization	IDA IDA: Inferred from direct assay	24726324	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	27974568	GOA
involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	16289642	GOA
involved in miRNA-mediated post-transcriptional gene silencing	IMP IMP: Inferred from mutant phenotype	17507929	GOA
involved in positive regulation of mRNA catabolic process	IDA IDA: Inferred from direct assay	24726324	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	23093941	GOA
involved in retrotransposon silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	30122351	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	16289642	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	30122351	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOV10 Protein Structure

AAA_11

AAA_12

0
200
400
600
800
1003 a.a.

Protein Preferred Names	Protein Names
helicase MOV-10	Mov10, Moloney leukemia virus 10, homolog

MOV10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MOV10	Q9HCE1	IGF2BP1	Homo sapiens	Q9NZI8	Anti Tag CoIP	20543829
Cross	MOV10	Q9HCE1	Cbx7	Mus musculus	Q8VDS3	Pull Down	20543829
Cross	MOV10	Q9HCE1	Cbx7	Mus musculus	Q8VDS3	Anti Tag CoIP	20543829
Cross	MOV10	Q9HCE1	shdag_hdvd3	Hepatitis delta virus	P0C6L3	Anti Tag CoIP	18552826
Intra	MOV10	Q9HCE1	PCGF2	Homo sapiens	P35227	Anti Bait CoIP	20543829
Intra	MOV10	Q9HCE1	PCGF2	Homo sapiens	P35227	Anti Tag CoIP	20543829
Intra	MOV10	Q9HCE1	BMI1	Homo sapiens	P35226	Anti Bait CoIP	20543829
Intra	MOV10	Q9HCE1	BMI1	Homo sapiens	P35226	Anti Tag CoIP	20543829
Cross	MOV10	Q9HCE1	N	SARS-CoV-2	P0DTC9	Confocal	35107372
Cross	MOV10	Q9HCE1	N	SARS-CoV-2	P0DTC9	Anti Bait CoIP	35107372
Intra	MOV10	Q9HCE1	TIAL1	Homo sapiens	Q01085	Anti Bait CoIP	34517762
Intra	MOV10	Q9HCE1	CBX7	Homo sapiens	O95931	Anti Bait CoIP	20543829
Intra	MOV10	Q9HCE1	CBX7	Homo sapiens	O95931	Anti Tag CoIP	20543829
Intra	MOV10	Q9HCE1	CBX6	Homo sapiens	O95503	Anti Tag CoIP	20543829
Intra	MOV10	Q9HCE1	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	21903422
Intra	MOV10	Q9HCE1	CBX8	Homo sapiens	Q9HC52	Anti Tag CoIP	20543829
Intra	MOV10	Q9HCE1	CBX8	Homo sapiens	Q9HC52	Anti Bait CoIP	20543829

Cross: Cross-species interaction Intra: Intraspecies interaction

MOV10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81924	MOV10 Antibody (YA1669)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08603	MOV10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08604	MOV10L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22648	Mov10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29162	Mov10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MOV10	VGNC	VGNC:106410
Felis catus	MOV10	VGNC	VGNC:68302
Mus musculus	MOV10	MGD	MGI:97054
Canis familiaris	MOV10	VGNC	VGNC:43327
Bos taurus	MOV10	VGNC	VGNC:31566
Rattus norvegicus	MOV10	RGD	RGD:1598327
Others	MOV10	NCBI