ABCB5 - ATP binding cassette subfamily B member 5 Gene

Also Known as ABCB5beta; EST422562; ABCB5alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 340273

About ABCB5

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:20,615,667-20,757,008 (from NCBI)

This gene has 6 transcripts (splice variants), 136 orthologues and 10 paralogues. Low expression observed in reference dataset.

Summary

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

ABCB5 Products (4)

mRNA	Protein	Name
NM_001163941.2	NP_001157413.1	ATP-binding cassette sub-family B member 5 isoform 1
NM_001163942.2	NP_001157414.1	ATP-binding cassette sub-family B member 5 isoform 3
NM_001163993.3	NP_001157465.1	ATP-binding cassette sub-family B member 5 isoform 4
NM_178559.6	NP_848654.3	ATP-binding cassette sub-family B member 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables efflux transmembrane transporter activity	IDA IDA: Inferred from direct assay	12960149	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of membrane potential	IDA IDA: Inferred from direct assay	12960149	GOA
involved in transmembrane transport	IDA IDA: Inferred from direct assay	12960149	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12960149	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCB5 Protein Structure

ABC_membrane

ABC_tran

ABC_membrane

ABC_tran

0
200
400
600
800
1000
1200
1257 a.a.

Protein Preferred Names	Protein Names
ATP-binding cassette sub-family B member 5	ABCB5 P-gp

Recombinant ABCB5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7621	ABCB5 Protein, Human (Trx)	Q2M3G0-4 (I586-V692)	≥ 85%, as determined by reducing SDS-PAGE.

ABCB5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80527	ABCB5 Antibody (YA836)	WB, ICC/IF	Human
HY-P80527A	ABCB5 Antibody (YA836)(PBS only)	WB, ICC/IF	Human
HY-P85662	ABCB5 Antibody (YA5354)	WB, IHC-P, ICC/IF,	Human

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Conjunctival Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Conjunctiva Conjunctival Epidermoid Carcinoma Invasive Squamous Cell Carcinoma Of The Conjunctiva Ocular Surface Squamous Neoplasia
Cardiomyopathy, Dilated, 1o	Dilated Cardiomyopathy 1o CMD1O Dilated Cardiomyopathy With Ventricular Tachycardia Cardiomyopathy, Dilated, With Ventricular Tachycardia Cardiomyopathy, Dilated 1o Cardiomyopathy, Dilated, Type 1o
Recessive Dystrophic Epidermolysis Bullosa	Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type Rdeb, Hallopeau-Siemens Type Severe Generalized Rdeb Severe Generalized Recessive Dystrophic Epidermolysis Bullosa Rdeb Generalisata Gravis Rdeb, Severe Generalized Rdeb-Sev Gen Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized Hallopeau-Siemens Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00052	ABCB5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18646	Abcb5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25131	Abcb5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990327	Anti-ACVR2B Antibody	Inhibitor	99.2%	Unkown
HY-P990325	Anti-ABCB5 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ABCB5	VGNC	VGNC:49905
Felis catus	ABCB5	VGNC	VGNC:69335
Mus musculus	ABCB5	MGD	MGI:1924956
Macaca mulatta	ABCB5	VGNC	VGNC:80321
Bos taurus	ABCB5	VGNC	VGNC:25464
Rattus norvegicus	ABCB5	RGD	RGD:1566342
Others	ABCB5	NCBI