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Cat. No.: HY-P85662

ABCB5 Antibody (YA5354)

Name: ABCB5 Antibody (YA5354)
Brand: MedChemExpress
SKU: HY-P85662
Availability: PreOrder

(Synonyms: ABCB5; ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5)

ABCB5 Antibody (YA5354) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ABCB5.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	IHC-P IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio	1:2000	1:200	1:50-300

Description

ABCB5 Antibody (YA5354) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to ABCB5.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 90 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Immunogen

Synthetic Peptide of ABCB5

Purification

affinity chromatography.

Conjugation

Non-conjugated

Modification

Unmodified

Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

ABCB5 is an Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair^[1]^[2]^[3]^[4].
Subcellular Localization

Cell membrane; Multi-pass membrane protein
Expression

Tissue_specificity:In epidermal melanocytes, CD133-expressing progenitor cells express this protein (protein level) . This protein is widely expressed and specifically expressed in pigment cells. It is highly expressed in various malignant tissues: highly expressed in clinical melanoma and lowly expressed in normal skin. In melanoma, this protein marks malignant melanoma initiating cells (MMICs) , which have unlimited self-renewal capacity, leading to irreversible tumor progression and metastasis, thus triggering clinical malignancy. This protein is also highly expressed in various leukemia cells. It is also expressed in the basal limbal epithelium.
Isoforms & Post-Translational Modification

Q2M3G0 has 4 isomers: Q2M3G0-4: 138641 Da (predicted); Q2M3G0-2: 14691 Da (predicted); Q2M3G0-3: 14081 Da (predicted); Q2M3G0-1: 89832 Da (predicted).
SwissProt ID

Q2M3G0
Gene ID

340273 [NCBI]
Synonyms

ABCB5; ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5