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Cat. No.: HY-183849

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H9-KGDEVD-MMAE

H9-KGDEVD-MMAE is an antibody-drug conjugate that specifically binds to PRND to enable precise drug delivery to tumor vasculature and cancer cells. H9-KGDEVD-MMAE contains a linker cleavable by cathepsin B and caspase-3/7, allowing the release of MMAE in lysosomes. H9-KGDEVD-MMAE induces apoptosis, produces a bystander effect, and disrupts tumor vasculature. H9-KGDEVD-MMAE achieves deep tumor penetration and exhibits durable anti-tumor efficacy without systemic toxicity in preclinical models of highly vascularized malignant tumors. H9-KGDEVD-MMAE can be applied to research related to glioblastoma, sarcoma, and renal cell carcinoma.

For research use only. We do not sell to patients.

CAS No.: 1932672-71-3
Formula: C₈₅H₁₂₈N₁₄O₂₅
Molecular Weight:1746.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

H9-KGDEVD-MMAE Chemical Structure

CAS No.: 1932672-71-3

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Description

Chemical Information

CAS No. 1932672-71-3
Molecular Weight 1746.00
Formula C₈₅H₁₂₈N₁₄O₂₅
SMILES

CC(N[C@@H](CCCCNC(CCCCCN1C(C=CC1=O)=O)=O)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(NC2=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N3[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C4=CC=CC=C4)=O)CCC3)=O)=O)=O)=O)C=C2)=O)=O)=O)=O)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kim B, Lee H K, Choi S Y, et al. Tumor endothelial cell and cancer cell targeting anti-PRND antibody-drug conjugate to treat hypervascular tumors such as glioblastoma and sarcomas[J]. Cancer Research, 2026, 86(7_Supplement): 2649-2649.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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