PF-06663195
PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC50 values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research.
For research use only. We do not sell to patients.
- CAS No.: 1621585-22-5
- Formula: C18H18F3N3O2S
- Molecular Weight:397.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
10.1 μM
Compound: 13
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Inhibition of human ERG expressed in CHO cells
Inhibition of human ERG expressed in CHO cells
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[PMID: 25781223] |
| H4 | IC50 |
53 nM
Compound: 13
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Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay
Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay
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[PMID: 25781223] |
Chemical Information
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CAS No. 1621585-22-5
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Molecular Weight 397.41
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Formula C18H18F3N3O2S
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SMILES
FC[C@@H]1[C@@]2([H])[C@](N=C(S1)N)(C3=C(C=C(C=C3)F)F)CO[C@@H](C4=CC(C)=NO4)C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-06663195 Related Classifications
HY-138013 Related Classifications
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