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  4. EDTA hydrate sodium

EDTA hydrate sodium  (Synonyms: Ethylenediaminetetraacetic acid hydrate sodium)

Cat. No.: HY-W127774 Purity: 97.0%
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EDTA (Ethylenediaminetetraacetic acid) hydrate sodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). EDTA hydrate sodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. EDTA hydrate sodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. EDTA hydrate sodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research.

For research use only. We do not sell to patients.

CAS No. : 85715-60-2

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10 mM * 1 mL in Water
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Based on 24 publication(s) in Google Scholar

Other Forms of EDTA hydrate sodium:

EDTA hydrate sodium Related Antibodies

Top Publications Citing Use of Products

    EDTA hydrate sodium purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672.  [Abstract]

    Representative images of CHMP4–GFP puncta (arrowheads; left) and percentage of CHMP4 speckle+ (top right) or Annexin V+ (bottom right) cells in BMDMs incubated with PBS, 15 µM SK56, 2 mM EDTA or EDTA + SK56 at 2 h after the addition of 1 μg/ml LPS + 10 μM nigericin; scale bar, 50 µm; n = 5 repeats

    • Biological Activity

    • Purity & Documentation

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    • Customer Review

    Description

    EDTA (Ethylenediaminetetraacetic acid) hydrate sodium is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). EDTA hydrate sodium has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. EDTA hydrate sodium decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. EDTA hydrate sodium can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research[1][2][3][4][5][6][7].

    In Vitro

    EDTA hydrate sodium has a strong bactericidal effect on the cell wall of P. aeruginosa and a. faecalis[4].
    EDTA (0.005-0.01 M) hydrate sodium has good heavy metal extraction in contaminated silty-clay-loam soil columns, can extract Pb, Cd and Zn in a concentration-dependent way with an extraction efficiency sequence of Pb > Cd > Zn[6].
    EDTA (1.2 mM) hydrate sodium enhances the activity of the CRE driving promoter by activating T-cell death-associated gene 8 (TDAG8) in HEK293T cells, thereby enhancing the production of cAMP in the cells[7].
    When EDTA hydrate sodium is prepared, NaOH is needed to adjust it in order to dissolve it. A relatively large amount of NaOH is required, and the dissolution is instantaneous, so NaOH needs to be added slowly, little by little.

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    EDTA hydrate sodium Related Antibodies
    In Vivo

    EDTA (60 mg/kg; Intraperitoneal injection; Three times per week for three weeks) hydrate sodium can reduce liver fibrosis, lipid peroxidation and liver inflammation in CCl4 induced liver fibrosis rats, and has antioxidant and anti-inflammatory activities[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rat model of cirrhosis induced by CCl4[5]
    Dosage: 60 mg/kg, 120 mg/kg, 240 mg/kg
    Administration: Intraperitoneal injection (i.p.); Three times per week for 3 weeks (during this period, CCl4 administration continued). After CCl4 and mineral oil mixture treatment (200 μL/mouse; i.p.; Three times per week for eight weeks).
    Result: Kept kept all the rats alive at the 60 mg/kg dose, but died at 120 and 240 mg/kg.
    Reduced fibrosis of the liver in surviving rats (20%).
    Animal Model: Male Wistar rat model of cirrhosis induced by CCl[5]
    Dosage: 60 mg/kg
    Administration: Intraperitoneal injection (i.p.); Three times per week for 11 weeks. (Preventive Ethylenediaminetetraacetic acid (EDTA) group: EDTA and CCl4 were administered during 11 weeks, three times per week on alternate days).
    Intraperitoneal injection (i.p.); Three times per week. After CCl4 treatment (i.p.; Three times per week for eight weeks) (Therapeutic EDTA group: EDTA and CCl4 were administered for 3 weeks, three times per week on alternate days).
    Result: Increased sod activity by 50% in the preventive EDTA group. (Compared with untreated EDTA group)
    Increased Cp activity in the preventive EDTA (30%) and therapeutic EDTA (20%) groups. (Compared with the fibrotic group)
    Decreased mRNA expression of the pro-inflammatory molecule (TNF-α and LI-6) and the profibrogenic molecules (TGF-β and αCOLI) in both the prevention and treatment groups.
    Clinical Trial
    Molecular Weight

    376.20

    Formula

    C10H13N2Na3O8 · xH2O
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])CN(CC(O[Na])=O)CCN(CC(O[Na])=O)CC(O)=O.O.[x]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Store at room temperature, keep dry and cool

    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    H2O : 16.67 mg/mL (44.31 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.6582 mL 13.2908 mL 26.5816 mL
    5 mM 0.5316 mL 2.6582 mL 5.3163 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 97.0%

    SDS (393 KB)

    COA (251 KB) HNMR (111 KB) LCMS (198 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.6582 mL 13.2908 mL 26.5816 mL 66.4540 mL
    5 mM 0.5316 mL 2.6582 mL 5.3163 mL 13.2908 mL
    10 mM 0.2658 mL 1.3291 mL 2.6582 mL 6.6454 mL
    15 mM 0.1772 mL 0.8861 mL 1.7721 mL 4.4303 mL
    20 mM 0.1329 mL 0.6645 mL 1.3291 mL 3.3227 mL
    25 mM 0.1063 mL 0.5316 mL 1.0633 mL 2.6582 mL
    30 mM 0.0886 mL 0.4430 mL 0.8861 mL 2.2151 mL
    40 mM 0.0665 mL 0.3323 mL 0.6645 mL 1.6614 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    EDTA hydrate sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    EDTA hydrate85715-60-2Ethylenediaminetetraacetic acid hydrateSODBiochemical Assay ReagentsBacterialSuperoxide DismutaseAnticoagulantAnti-hypercalcemicProtein purificationProtein storageHEK293TTDAG8cAMPChelating agentHypercalcemiaHepatic fibrosisInhibitorinhibitorinhibit

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