Map4k2 - mitogen-activated protein kinase kinase kinase kinase 2 Gene

Also Known as GCK; BL44; Rab8ip

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26412

About Map4k2

Chromosome 19: 6,391,165-6,405,645 forward strand.GRCm39:CM001012.3

This gene has 23 transcripts (splice variants), 101 orthologues and 35 paralogues. Broad expression in thymus adult (RPKM 169.4), spleen adult (RPKM 142.6) and 23 other tissues.

Summary

Predicted to enable ATP binding activity; MAP kinase kinase kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in vesicle targeting. Predicted to be located in Golgi apparatus and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Map4k2 Products (2)

mRNA Protein Name
NM_001291787.1 NP_001278716.1 mitogen-activated protein kinase kinase kinase kinase 2 isoform 2
NM_009006.3 NP_033032.1 mitogen-activated protein kinase kinase kinase kinase 2 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in vesicle targeting IDA
IDA: Inferred from direct assay
8643544 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map4k2 Protein Structure

STKc_MAP4K3_like

STKc_MAP4K3_like: cd06613 (15 - 271)

CNH

CNH: smart00036 (488 - 800)

  • 0
  • 200
  • 400
  • 600
  • 821 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 2

  • MAPK/ERK kinase kinase kinase 2

  • MEK kinase kinase 2

  • MEKKK 2

  • RAB8 interacting protein

  • germinal center kinase

  • rab8-interacting protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15434 NG25 Inhibitor 98.68% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-77251 TAK1/MAP4K2 inhibitor 1 Inhibitor 99.91% Unkown
HY-123714 TL4-12 99.82% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-15434A NG25 trihydrochloride Inhibitor / Unkown
HY-RS08074 MAP4K2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08075 Map4k2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08076 Map4k2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k2 NCBI NCBI:5871