KDM3B - lysine demethylase 3B Gene

Also Known as 5qNCA; DIJOS; NET22; C5orf7; JMJD1B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51780

About KDM3B

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,352,685-138,437,027 (from NCBI)

This gene has 9 transcripts (splice variants), 215 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 15.2), thyroid (RPKM 13.7) and 25 other tissues.

Summary

Predicted to enable chromatin DNA binding activity; histone H3-methyl-lysine-9 demethylase activity; and transcription coregulator activity. Predicted to be involved in histone H3-K9 demethylation and regulation of transcription by RNA polymerase II. Located in nucleoplasm. Biomarker of acute lymphoblastic leukemia; breast cancer; colorectal cancer; and lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Apr 2022]

KDM3B Products (1)

mRNA Protein Name
NM_016604.4 NP_057688.3 lysine-specific demethylase 3B

KDM3B Protein Structure

JmjC

JmjC: JmjC domain, hydroxylase (1599 - 1704)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1761 a.a.
Protein Preferred Names Protein Names

lysine-specific demethylase 3B

  • [histone H3]-dimethyl-L-lysine(9) demethylase 3B

Recombinant KDM3B Proteins

Cat. No. Product Name Accession Purity
HY-P71585 KDM3B Protein, Human (Myc, His-SUMO) Q7LBC6-1 (M1498-R1721) ≥ 90%, as determined by reducing SDS-PAGE.

KDM3B Antibodies

Cat. No. Product Name Application Reactivity
HY-P86931 KDM3B Antibody (YA6624) WB, IHC-P, ICC/IF, FC Human, Mouse

Related Diseases

Diseases Alias
Diets-Jongmans Syndrome

  • DIJOS

  • Intellectual Developmental Disorder With Distinctive Facial Dysmorphism

  • Iddfd
Rare Genetic Epilepsy
Rare Genetic Intellectual Disability
Otopalatodigital Syndrome, Type I

  • Otopalatodigital Syndrome Type 1

  • Taybi Syndrome

  • OPD1

  • Opd Syndrome 1

  • Oto-Palato-Digital Syndrome Type 1

  • Opd I Syndrome

  • Oto-Palato-Digital Syndrome, Type I

  • Otopalatodigital Syndrome Type I

  • Opd Syndrome

  • Cranioorodigital Syndrome

  • Faciopalatoosseous Syndrome

  • Fpo

  • Opd Syndrome, Type 1

  • Otopalatodigital Syndrome 1
Hereditary Wilms' Tumor

  • Hereditary Wilms Tumor

  • Hereditary Wilms Tumour

  • Hereditary Wilms' Tumour

  • Wt1
Small Cell Carcinoma

  • Small Cell Carcinoma, Intermediate Cell

  • Intermediate Cell Small Cell Carcinoma

  • Small Cell Carcinoma - Intermediate Cell

  • Small Cell Carcinoma Of Lung

  • Carcinoma, Small Cell
Adult Medulloblastoma

  • Adult Brain Medulloblastoma

  • Medulloblastoma, Adult
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-139348 PFI-90 99.86% Unkown
HY-168593 PROTAC KDM3 degrader-1 99.07% Unkown
HY-162301 P3FI-63 Inhibitor 98.49% Unkown
HY-RS07212 KDM3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18179 Kdm3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24653 Kdm3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KDM3B VGNC VGNC:63071
Rattus norvegicus KDM3B RGD RGD:1583423
Bos taurus KDM3B VGNC VGNC:30526
Canis familiaris KDM3B VGNC VGNC:42323
Mus musculus KDM3B MGD MGI:1923356
Macaca mulatta KDM3B VGNC VGNC:73823
Others KDM3B NCBI