Gremubamab
Based on 1 Customer Validation
Gremubamab (MEDI3902) is a humanized IgG1 kappa anti-PcrV/Psl monoclonal antibody. Gremubamab binds to the PA PcrV protein and Psl exopolysaccharide. Gremubamab has the potential for the research of pseudomonas aeruginosa infections.
For research use only. We do not sell to patients.
- Purity: 98.40%
- CAS No.: 1800381-36-5
- Molecular Weight:200.46 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
[VH-CH1-scFv-VH-VK-h-CH2-CH3_L-kappa]2
Pseudomonas aeruginosa
PcrV & PslG
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbits (acute pneumonia model)[2]
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Dosage:1, 5, 15 mg/kg
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Administration:I.v.; at 1 h postinfection
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Result:Improved survival outcomes in a dose-dependent manner in a rabbit acute pneumonia model.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[VH-CH1-scFv-VH-VK-h-CH2-CH3_L-kappa]2
ELISA, FACS, Functional assay
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Immobilized Pseudomonas aeruginosa can bind Gremubamab. The EC50 for this effect is 136.6 ng/mL.
Chemical Information
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CAS No. 1800381-36-5
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Appearance Liquid
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Molecular Weight 200.46 kDa
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Color Colorless to light yellow
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SMILES
[Gremubamab]
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Synonyms
MEDI3902
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Chastre J, et al. Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial. Crit Care. 2022 Nov 15;26(1):355. [Content Brief]
[2]. Le HN, et al. Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00710-19. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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