Fmoc-Val-Cit-PAB-Duocarmycin TM
Based on 1 Customer Validation
Fmoc-Val-Cit-PAB-Duocarmycin TM is a agent-linker conjugate for ADC by using the antitumor antibiotic, Duocarmycin TM, linked via Fmoc-Val-Cit-PAB.
For research use only. We do not sell to patients.
- Purity: 99.0%
- Formula: C58H60ClN7O10
- Molecular Weight:1050.59
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
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Duocarmycins |
Chemical Information
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Appearance Solid
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Molecular Weight 1050.59
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Formula C58H60ClN7O10
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Color White to yellow
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SMILES
O=C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(C=C1)COC2=CC3=C(C4=C2C=CC=C4)[C@@H](CN3C(C5=CC6=C(C(OC)=C(C(OC)=C6)OC)N5)=O)CCl)=O)[C@@H](NC(OCC7C8=CC=CC=C8C9=CC=CC=C79)=O)C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (95.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (250 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.9518 mL | 4.7592 mL | 9.5185 mL | 23.7962 mL |
| 5 mM | 0.1904 mL | 0.9518 mL | 1.9037 mL | 4.7592 mL | |
| 10 mM | 0.0952 mL | 0.4759 mL | 0.9518 mL | 2.3796 mL | |
| 15 mM | 0.0635 mL | 0.3173 mL | 0.6346 mL | 1.5864 mL | |
| 20 mM | 0.0476 mL | 0.2380 mL | 0.4759 mL | 1.1898 mL | |
| 25 mM | 0.0381 mL | 0.1904 mL | 0.3807 mL | 0.9518 mL | |
| 30 mM | 0.0317 mL | 0.1586 mL | 0.3173 mL | 0.7932 mL | |
| 40 mM | 0.0238 mL | 0.1190 mL | 0.2380 mL | 0.5949 mL | |
| 50 mM | 0.0190 mL | 0.0952 mL | 0.1904 mL | 0.4759 mL | |
| 60 mM | 0.0159 mL | 0.0793 mL | 0.1586 mL | 0.3966 mL | |
| 80 mM | 0.0119 mL | 0.0595 mL | 0.1190 mL | 0.2975 mL |
Fmoc-Val-Cit-PAB-Duocarmycin TM Related Classifications
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