2-Methylbutyryl-CoA
2-Methylbutyryl-CoA is a branched-chain acyl-CoA substrate. It serves as the preferred substrate for potato 2-methylbutyryl-CoA dehydrogenase (2MBCD), which catalyzes its α,β-dehydrogenation.
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- CAS No.: 6712-02-3
- Formula: C26H44N7O17P3S
- Molecular Weight:851.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
2-Methylbutyryl-CoA (0.1-50 μM) is the substrate for maximal enzymatic activity of purified recombinant potato 2MBCD (Km = 1.0 μM), while human IVD mutants modified to match 2MBCD's active site residues show altered specificity toward 2-methylbutyryl-CoA, with the quintuple mutant losing isovaleryl-CoA activity entirely[1].
2-Methylbutyryl-CoA is accepted as a starter substrate by recombinant LipPks1+TE from Streptomyces aureofaciens Tü117, catalyzing the formation of 3-hydroxy-2,4-dimethylhexanoate with a kcat/KM of 237.0 M-1s-1[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6712-02-3
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Molecular Weight 851.65
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Formula C26H44N7O17P3S
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(C(CC)C)=O)=O)=O)O)C)=O)=O)O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Methylbutyryl-CoA Related Classifications
HY-E70239 Related Classifications
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- 2-Methylbutyryl-CoA
- 6712-02-3
- Endogenous Metabolite
- LipPks1 polyketide synthase subunit
- potato 2-methylbutyryl-CoA dehydrogenase
- recombinant potato 2MBCD
- Streptomyces aureofaciens Tü117
- isovaleryl-CoA
- 3-hydroxy polyketide
- 3-hydroxy-2,4-dimethylhexanoate
- methylmalonyl-CoA
- quintuple mutant human isovaleryl-CoA dehydrogenase
- human short/branched-chain acyl-CoA dehydrogenase
- Inhibitor
- inhibitor
- inhibit