BIRC2 - baculoviral IAP repeat containing 2 Gene

Also Known as API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 329

About BIRC2

Cytogenetic location: 11q22.2 Genomic coordinates (GRCh38): 11:102,347,214-102,378,670 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 16.6), gall bladder (RPKM 15.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of a family of proteins that inhibits Apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits Apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

BIRC2 Products (3)

mRNA	Protein	Name
NM_001256163.1	NP_001243092.1	baculoviral IAP repeat-containing protein 2 isoform 1
NM_001166.5	NP_001157.1	baculoviral IAP repeat-containing protein 2 isoform 1
NM_001256166.2	NP_001243095.1	baculoviral IAP repeat-containing protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables FBXO family protein binding	IPI IPI: Inferred from physical interaction	16510124	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22493164	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11084335	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	18239673	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	21653699	GOA
enables transferase activity	EXP EXP: Inferred from Experiment	19008929	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	16510124	GOA
enables ubiquitin-protein transferase activity	EXP EXP: Inferred from Experiment	10797013	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	11907583	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19153467	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	21525013	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	21931591	GOA
involved in positive regulation of protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	21931591	GOA
involved in positive regulation of protein monoubiquitination	IDA IDA: Inferred from direct assay	21931591	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	11907583	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	11907583	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21737330	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	15665297	GOA
involved in regulation of necroptotic process	IMP IMP: Inferred from mutant phenotype	21737330	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16510124	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15665297	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIRC2 Protein Structure

BIR

CARD

zf-C3HC4_3

0
100
200
300
400
500
618 a.a.

Protein Preferred Names	Protein Names
baculoviral IAP repeat-containing protein 2	IAP homolog B IAP-2 NFR2-TRAF signalling complex protein RING finger protein 48 RING-type E3 ubiquitin transferase BIRC2 TNFR2-TRAF-signaling complex protein 2 apoptosis inhibitor 1 cellular inhibitor of apoptosis 1 inhibitor of apoptosis protein 2

BIRC2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BIRC2	Q13490	BOLA1	Homo sapiens	Q9Y3E2	Y2H Prey Pooling	25416956
Intra	BIRC2	Q13490	BOLA1	Homo sapiens	Q9Y3E2	Validated Y2H	25416956
Intra	BIRC2	Q13490	BOLA1	Homo sapiens	Q9Y3E2	Validated Y2H	32296183
Intra	BIRC2	Q13490	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	BIRC2	Q13490	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	BIRC2	Q13490	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	BIRC2	Q13490	OTUB1	Homo sapiens	Q96FW1	Anti Bait CoIP	23524849
Intra	BIRC2	Q13490	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	23524849
Intra	BIRC2	Q13490	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	BIRC2	Q13490	EAF2	Homo sapiens	Q96CJ1	Validated Y2H	25416956
Intra	BIRC2	Q13490	EAF2	Homo sapiens	Q96CJ1	Y2H Prey Pooling	25416956
Intra	BIRC2	Q13490	RIPK3	Homo sapiens	Q9Y572	Anti Tag CoIP	21931591
Intra	BIRC2	Q13490	RIPK3	Homo sapiens	Q9Y572	Pull Down	21931591
Intra	BIRC2	Q13490	RIPK3	Homo sapiens	Q9Y572	Enzymatic Study	21931591
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	PLA	25241761
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	Anti Bait CoIP	16282325
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	33961781
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	Y2H Pooling	16189514
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	Pull Down	16282325
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	23524849
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	ViroTrap	30561431
Intra	BIRC2	Q13490	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	16282325
Intra	BIRC2	Q13490	RIPK1	Homo sapiens	Q13546	ViroTrap	30561431
Intra	BIRC2	Q13490	RIPK1	Homo sapiens	Q13546	Pull Down	21931591
Intra	BIRC2	Q13490	RIPK1	Homo sapiens	Q13546	Enzymatic Study	21931591
Intra	BIRC2	Q13490	RIPK1	Homo sapiens	Q13546	Anti Tag CoIP	21931591
Intra	BIRC2	Q13490	RIPK2	Homo sapiens	O43353	Pull Down	21931591
Intra	BIRC2	Q13490	RIPK2	Homo sapiens	O43353	Enzymatic Study	21931591
Intra	BIRC2	Q13490	TRAF1	Homo sapiens	Q13077	ViroTrap	30561431
Intra	BIRC2	Q13490	TRAF1	Homo sapiens	Q13077	Anti Tag CoIP	33961781
Intra	BIRC2	Q13490	TRAF1	Homo sapiens	Q13077	Anti Tag CoIP	28514442
Intra	BIRC2	Q13490	TRAF1	Homo sapiens	Q13077	Anti Tag CoIP	23524849
Intra	BIRC2	Q13490	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	25416956
Intra	BIRC2	Q13490	EXOSC5	Homo sapiens	Q9NQT4	Validated Y2H	32296183
Intra	BIRC2	Q13490	EXOSC5	Homo sapiens	Q9NQT4	Y2H Array	25416956
Intra	BIRC2	Q13490	EXOSC5	Homo sapiens	Q9NQT4	Y2H Prey Pooling	25416956
Intra	BIRC2	Q13490	PPM1K	Homo sapiens	Q8N3J5	Validated Y2H	32296183
Intra	BIRC2	Q13490	PPM1K	Homo sapiens	Q8N3J5	Y2H Array	25416956
Intra	BIRC2	Q13490	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	BIRC2	Q13490	RAC1	Homo sapiens	P63000	Pull Down	22117219
Intra	BIRC2	Q13490	RIPK4	Homo sapiens	P57078	Pull Down	21931591
Intra	BIRC2	Q13490	RIPK4	Homo sapiens	P57078	Enzymatic Study	21931591
Intra	BIRC2	Q13490	RIPK4	Homo sapiens	P57078	Anti Tag CoIP	21931591
Intra	BIRC2	Q13490	CASP9	Homo sapiens	P55211	Validated Y2H	25416956
Intra	BIRC2	Q13490	CASP9	Homo sapiens	P55211	Y2H Array	25416956
Intra	BIRC2	Q13490	CASP9	Homo sapiens	P55211	Y2H Array	31515488
Intra	BIRC2	Q13490	CASP9	Homo sapiens	P55211	Y2H Prey Pooling	25416956
Intra	BIRC2	Q13490	CASP9	Homo sapiens	P55211	SPR	19153467
Intra	BIRC2	Q13490	HTRA2	Homo sapiens	O43464	Anti Tag CoIP	33961781
Intra	BIRC2	Q13490	HTRA2	Homo sapiens	O43464	Anti Tag CoIP	11583623
Intra	BIRC2	Q13490	DIABLO	Homo sapiens	Q9NR28	Anti Tag CoIP	33961781
Intra	BIRC2	Q13490	DIABLO	Homo sapiens	Q9NR28	CoIP	10929712
Intra	BIRC2	Q13490	DIABLO	Homo sapiens	Q9NR28	SPR	19153467
Intra	BIRC2	Q13490	DIABLO	Homo sapiens	Q9NR28	Pull Down	16282325
Intra	BIRC2	Q13490	BIRC7	Homo sapiens	Q96CA5	Y2H Array	25416956
Intra	BIRC2	Q13490	BIRC7	Homo sapiens	Q96CA5	Y2H Array	31515488
Intra	BIRC2	Q13490	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	BIRC2	Q13490	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	BIRC2	Q13490	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	BIRC2	Q13490	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	BIRC2	Q13490	TSGA10	Homo sapiens	Q9BZW7	Y2H Array	25416956
Intra	BIRC2	Q13490	TSGA10	Homo sapiens	Q9BZW7	Y2H	21516116
Intra	BIRC2	Q13490	GCC1	Homo sapiens	Q96CN9	Y2H Prey Pooling	25416956
Intra	BIRC2	Q13490	GCC1	Homo sapiens	Q96CN9	Validated Y2H	25416956
Intra	BIRC2	Q13490	GCC1	Homo sapiens	Q96CN9	Validated Y2H	32296183
Intra	BIRC2	Q13490	GCC1	Homo sapiens	Q96CN9	Y2H Array	25416956
Intra	BIRC2	Q13490	NMB	Homo sapiens	P08949	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

BIRC2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82755	cIAP1 Antibody (YA2500)	WB, ICC/IF	Human
HY-P82755A	cIAP1 Antibody (YA2500)(PBS only)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Follicular Lymphoma	Lymphoma, Follicular Lymphoma Follicular Brill-Symmers' Disease Large Cell Follicular Non-Hodgkin Lymphoma Diffuse Follicle Centre Lymphoma Diffuse Follicular Lymphoma Nos Follicular Nodular Non-Hodgkin Lymphoma, Unspecified Follicular Large Cell Cleaved Or Noncleaved Lymphoma Large Cell Follicular Noncleaved Lymphoma Follicular Lymphoma With Or Without Diffuse Areas Histiocytic Follicular Lymphoma Histiocytic Nodular Lymphoma Histiocytic Nodular Malignant Lymphoma Large Cell Follicular Lymphoma Large Cell Noncleaved Follicular Lymphoma Large Cell Noncleaved Follicular Malignant Lymphoma Nodular Reticulum Cell Sarcoma Noncleaved Follicular Lymphoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50685	A 410099.1	Inhibitor	99.30%	Unkown
HY-RS01507	BIRC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01508	Birc2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01509	Birc2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01512	Birc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BIRC2	MGD	MGI:1197009
Macaca mulatta	BIRC2	VGNC	VGNC:97740
Bos taurus	BIRC2	VGNC	VGNC:26499
Canis familiaris	BIRC2	VGNC	VGNC:38460
Rattus norvegicus	BIRC2	RGD	RGD:620690
Felis catus	BIRC2	VGNC	VGNC:81907
Others	BIRC2	NCBI