EAF2 - ELL associated factor 2 Gene

Also Known as U19; BM040; TRAITS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55840

About EAF2

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,835,209-121,886,526 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 6.9), lymph node (RPKM 6.3) and 18 other tissues.

Summary

Enables transcription elongation regulator activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of transcription elongation from RNA polymerase II promoter. Part of transcription elongation factor complex. Biomarker of prostate Cancer. [provided by Alliance of Genome Resources, Apr 2022]

EAF2 Products (2)

mRNA Protein Name
NM_001320041.2 NP_001306970.1 ELL-associated factor 2 isoform 2
NM_018456.6 NP_060926.2 ELL-associated factor 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17395368 GOA
enables transcription elongation factor activity IMP
IMP: Inferred from mutant phenotype
32087315 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16114057 GOA
involved in regulation of transcription elongation by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
32087315 GOA
Cellular Component GO Annotation Evidence References Source
part of transcription elongation factor complex IDA
IDA: Inferred from direct assay
22195968 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EAF2 Protein Structure

EAF

EAF: RNA polymerase II transcription elongation factor (16 - 115)

  • 0
  • 100
  • 200
  • 260 a.a.
Protein Preferred Names Protein Names

ELL-associated factor 2

  • testosterone-regulated apoptosis inducer and tumor suppressor protein

EAF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EAF2 Q96CJ1 BEND7 Homo sapiens Q8N7W2-2
BFG-2H
27107012
Intra
EAF2 Q96CJ1 BEND7 Homo sapiens Q8N7W2-2
Validated Y2H
25416956
Intra
EAF2 Q96CJ1 BEND7 Homo sapiens Q8N7W2-2
Y2H Array
25416956
Intra
EAF2 Q96CJ1 TFPT Homo sapiens P0C1Z6
Y2H
17395368
Intra
EAF2 Q96CJ1 PSME3 Homo sapiens P61289
Y2H
21516116
Intra
EAF2 Q96CJ1 PSME3 Homo sapiens P61289
BFG-2H
27107012
Intra
EAF2 Q96CJ1 BIRC2 Homo sapiens Q13490
Y2H Array
25416956
Intra
EAF2 Q96CJ1 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra
EAF2 Q96CJ1 TRIM23 Homo sapiens P36406
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Eaf

  • Eosinophilic Angiocentric Fibrosis

  • Sinonasal Eosinophilic Angiocentric Fibrosis

  • Igg4-Related Eosinophilic Angiocentric Fibrosis
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03819 DMAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04120 EAF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20724 Eaf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27236 Eaf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EAF2 RGD RGD:628879
Canis familiaris EAF2 VGNC VGNC:40172
Macaca mulatta EAF2 VGNC VGNC:71884
Felis catus EAF2 VGNC VGNC:61701
Mus musculus EAF2 MGD MGI:2146616
Bos taurus EAF2 VGNC VGNC:28295
Others EAF2 NCBI