PPM1K - protein phosphatase, Mg2+/Mn2+ dependent 1K Gene

Also Known as BDP; PTMP; PP2Cm; MSUDMV; PP2Ckappa; UG0882E07

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 152926

About PPM1K

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,257,620-88,284,561 (from NCBI)

This gene has 10 transcripts (splice variants), 257 orthologues, 16 paralogues and is associated with 2 phenotypes. Broad expression in heart (RPKM 22.0), endometrium (RPKM 10.0) and 22 other tissues.

Summary

This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]

PPM1K Products (1)

mRNA Protein Name
NM_152542.5 NP_689755.3 protein phosphatase 1K, mitochondrial

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables manganese ion binding IDA
IDA: Inferred from direct assay
22291014 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22291014 GOA
enables protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
17374715 GOA
Biological Process GO Annotation Evidence References Source
involved in branched-chain amino acid catabolic process IMP
IMP: Inferred from mutant phenotype
29779826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPM1K Protein Structure

PP2C

PP2C: Protein phosphatase 2C (115 - 338)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1K, mitochondrial

  • PP2C domain-containing protein phosphatase 1K

PPM1K Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPM1K Q8N3J5 UBXN11 Homo sapiens Q5T124-6
Y2H Prey Pooling
32296183
Intra
PPM1K Q8N3J5 UBXN11 Homo sapiens Q5T124-6
Y2H Array
32296183
Intra
PPM1K Q8N3J5 BIRC2 Homo sapiens Q13490
Y2H Array
32296183
Intra
PPM1K Q8N3J5 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
25416956
Intra
PPM1K Q8N3J5 BIRC2 Homo sapiens Q13490
Validated Y2H
25416956
Intra
PPM1K Q8N3J5 BIRC2 Homo sapiens Q13490
Y2H Prey Pooling
32296183
Intra
PPM1K Q8N3J5 XIAP Homo sapiens P98170
Y2H Prey Pooling
32296183
Intra
PPM1K Q8N3J5 XIAP Homo sapiens P98170
Y2H Array
32296183
Intra
PPM1K Q8N3J5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
PPM1K Q8N3J5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
PPM1K Q8N3J5 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
PPM1K Q8N3J5 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
PPM1K Q8N3J5 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Maple Syrup Urine Disease, Mild Variant

  • MSUDMV
Intermediate Maple Syrup Urine Disease

  • Intermediate Bckd Deficiency

  • Intermediate Msud

  • Intermediate Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency
Maple Syrup Urine Disease

  • MSUD

  • Bckd Deficiency

  • Branched-Chain Ketoaciduria

  • Branched-Chain Alpha-Keto Acid Dehydrogenase Deficiency

  • Keto Acid Decarboxylase Deficiency

  • Maple Syrup Urine Disease, Type Ii

  • Branched Chain Ketoaciduria

  • Classic Maple Syrup Urine Disease

  • Intermittent Maple Syrup Urine Disease

  • Maple Syrup Urine Disease, Type Ia

  • Ketoacidaemia

  • Bckdh Deficiency

  • Branched-Chain 2-Ketoacid Dehydrogenase Deficiency

  • Thiamine-Responsive Maple Syrup Urine Disease

  • Intermediate Maple Syrup Urine Disease

  • Maple Syrup Urine Disease Type 1a

  • Maple Syrup Urine Disease Type 1b

  • Maple Syrup Urine Disease Type 2

  • Maple Syrup Urine Disease, Type Ib

  • Dihydrolipoamide Dehydrogenase Deficiency

  • Branched-Chain Ketoacid Dehydrogenase Deficiency

  • Maple Syrup Disease

  • Ketoacidemia

  • Classic Bckd Deficiency

  • Classic Msud

  • Classic Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Classic Branched-Chain Ketoaciduria

  • Thiamine-Responsive Bckd Deficiency

  • Thiamine-Responsive Msud

  • Thiamine-Responsive Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Intermittent Bckd Deficiency

  • Intermittent Msud

  • Intermittent Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency

  • Maple Syrup Urine Disease 1a

  • MSUD1A

  • Maple Syrup Urine Disease Type Ia

  • Msud Type Ia

  • Maple Syrup Urine Disease 1b

  • MSUD1B

  • Maple Syrup Urine Disease Type Ib

  • Msud Type Ib

  • Maple Syrup Urine Disease 2

  • MSUD2

  • Maple Syrup Urine Disease Type Ii

  • Msud Type Ii

  • Nadh Cytochrome B5 Reductase Deficiency

  • Lactic Acidosis, Congenital Infantile, Due To Lad Deficiency

  • Ketonemia

  • Maple Syrup Urine Disease, Type 1b

  • Ketoacid Decarboxylase Deficiency

  • Oxoacid Decarboxylase Deficiency

  • Branched Chain Ketoacid Dehydrogenase Deficiency

  • Msud - [Maple-Syrup-Urine Disease]

  • Ketoaminoacidaemia

  • Bckd - [Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency]

  • Maple-Syrup-Urine Disorder

  • Maple-Syrup-Urine Syndrome
Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency

  • BCKDKD

  • Branched-Chain Ketoacid Dehydrogenase Kinase Deficiency

  • Bckdk Deficiency

  • Autism-Epilepsy Syndrome Due To Branched Chain Ketoacid Dehydrogenase Kinase Deficiency
Organic Acidemia

  • Organic Aciduria

  • Disorder Of Organic Acid Metabolism

  • Organic Acid Metabolism Disorder

  • Organic Acidemias

  • Inherited Organic Acidemia

  • Organic Acidurias

  • Aciduria Organic
Inflammatory Bowel Disease 3

  • IBD3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10968 PPM1K Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21696 Ppm1k Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28214 Ppm1k Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPM1K VGNC VGNC:79976
Mus musculus PPM1K MGD MGI:2442111
Bos taurus PPM1K VGNC VGNC:33215
Macaca mulatta PPM1K VGNC VGNC:76109
Canis familiaris PPM1K VGNC VGNC:44870
Rattus norvegicus PPM1K RGD RGD:1308501
Others PPM1K NCBI