1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Frakefamide

Frakefamide 

Cat. No.: HY-106147
Handling Instructions

Frakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system.

For research use only. We do not sell to patients.

Frakefamide Chemical Structure

Frakefamide Chemical Structure

CAS No. : 188196-22-7

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Description

Frakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2].

In Vivo

Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

563.62

Formula

C₃₀H₃₄FN₅O₅

CAS No.

188196-22-7

Sequence

Tyr-Ala-Phe(4-F)-Phe-NH2

Sequence Shortening

YA-Phe(4-F)-Phe-NH2

SMILES

O=C(N[[email protected]](C(N)=O)CC1=CC=CC=C1)[[email protected]@H](NC([[email protected]@H](C)NC([[email protected]@H](N)CC(C=C2)=CC=C2O)=O)=O)CC(C=C3)=CC=C3F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

FrakefamideOpioid ReceptorInhibitorinhibitorinhibit

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Frakefamide
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HY-106147
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