1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Frakefamide TFA

Frakefamide TFA 

Cat. No.: HY-106147B
Handling Instructions

Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system.

For research use only. We do not sell to patients.

Frakefamide TFA Chemical Structure

Frakefamide TFA Chemical Structure

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Description

Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2].

In Vivo

Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2].

Molecular Weight

677.64

Formula

C₃₂H₃₅F₄N₅O₇

Sequence

Tyr-Ala-Phe(4-F)-Phe-NH2

Sequence Shortening

YA-Phe(4-F)-Phe-NH2

SMILES

O=C(N[[email protected]](C(N)=O)CC1=CC=CC=C1)[[email protected]@H](NC([[email protected]@H](C)NC([[email protected]@H](N)CC(C=C2)=CC=C2O)=O)=O)CC(C=C3)=CC=C3F.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FrakefamideOpioid ReceptorInhibitorinhibitorinhibit

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Frakefamide TFA
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HY-106147B
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