1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Frakefamide TFA

Frakefamide TFA 

Cat. No.: HY-106147B Purity: 99.18%
Handling Instructions

Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system.

For research use only. We do not sell to patients.

Frakefamide TFA Chemical Structure

Frakefamide TFA Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 224 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
25 mg USD 480 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Frakefamide TFA:

Top Publications Citing Use of Products
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  • Purity & Documentation

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Description

Frakefamide TFA is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2].

In Vivo

Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

677.64

Formula

C₃₂H₃₅F₄N₅O₇

Sequence

Tyr-Ala-Phe(4-F)-Phe-NH2

Sequence Shortening

YA-Phe(4-F)-Phe-NH2

SMILES

O=C(N[[email protected]](C(N)=O)CC1=CC=CC=C1)[[email protected]@H](NC([[email protected]@H](C)NC([[email protected]@H](N)CC(C=C2)=CC=C2O)=O)=O)CC(C=C3)=CC=C3F.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (368.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4757 mL 7.3785 mL 14.7571 mL
5 mM 0.2951 mL 1.4757 mL 2.9514 mL
10 mM 0.1476 mL 0.7379 mL 1.4757 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.07 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.18%

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Keywords:

FrakefamideOpioid ReceptorInhibitorinhibitorinhibit

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Product Name:
Frakefamide TFA
Cat. No.:
HY-106147B
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