CYPMPO
Based on 1 Customer Validation
CYPMPO is a spin-trapping reagent. CYPMPO, a cyclic DEPMPO-type nitrone, is evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. anti-oxidant and anti-tumor?activity.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 934182-09-9
- Formula: C10H18NO4P
- Molecular Weight:247.23
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
DMPO is often used as a spin trapping agent to detect oxygen-centered radicals. CYPMPO has a larger reaction rate constant with superoxide anion than DMPO and the superoxide adduct of CYPMPO is more stable than that of DMPO. CYPMPO (2.5?mM) acts as a spin-trap agent[2].
CYPMPO, a spin-trap, a cyclic DEPMPO-like nitrone trap, may provide new free radical information when used with mitochondria. CYPMPO has the preferential quality of having minimal mitochondrial toxicity at concentrations required for radical detection[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 934182-09-9
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Appearance Solid
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Molecular Weight 247.23
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Formula C10H18NO4P
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Color Off-white to light yellow
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SMILES
CC1(P2(OCC(C)(C)CO2)=O)[N+]([O-])=CCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMF : 25 mg/mL (101.12 mM; Need ultrasonic and warming)
Ethanol : 25 mg/mL (101.12 mM; Need ultrasonic and warming)
DMSO : 20 mg/mL (80.90 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Masato Kamibayashi, et al. Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Free Radic Res. 2006 Nov;40(11):1166-72. [Content Brief]
[2]. Ryohei Umeda, et al. Direct free radical scavenging effects of water-soluble HMG-CoA reductase inhibitors. J Clin Biochem Nutr. 2019 Jan;64(1):20-26. [Content Brief]
[3]. Matsuzaki S, et al. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry 2011, 50, 50, 10792-10803. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / DMF / Ethanol | 1 mM | 4.0448 mL | 20.2241 mL | 40.4482 mL | 101.1204 mL |
| 5 mM | 0.8090 mL | 4.0448 mL | 8.0896 mL | 20.2241 mL | |
| 10 mM | 0.4045 mL | 2.0224 mL | 4.0448 mL | 10.1120 mL | |
| 15 mM | 0.2697 mL | 1.3483 mL | 2.6965 mL | 6.7414 mL | |
| 20 mM | 0.2022 mL | 1.0112 mL | 2.0224 mL | 5.0560 mL | |
| 25 mM | 0.1618 mL | 0.8090 mL | 1.6179 mL | 4.0448 mL | |
| 30 mM | 0.1348 mL | 0.6741 mL | 1.3483 mL | 3.3707 mL | |
| 40 mM | 0.1011 mL | 0.5056 mL | 1.0112 mL | 2.5280 mL | |
| 50 mM | 0.0809 mL | 0.4045 mL | 0.8090 mL | 2.0224 mL | |
| 60 mM | 0.0674 mL | 0.3371 mL | 0.6741 mL | 1.6853 mL | |
| 80 mM | 0.0506 mL | 0.2528 mL | 0.5056 mL | 1.2640 mL | |
| DMF / Ethanol | 100 mM | 0.0404 mL | 0.2022 mL | 0.4045 mL | 1.0112 mL |
CYPMPO Related Classifications
HY-135152 Related Classifications
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