4L2-P13D
Based on 1 Customer Validation
4L2-P13D is an IL-11 antagonist with an IC50 of 2.8 μM. 4L2-P13D has a KD of 11 nM for hIL-11. 4L2-P13D exhibits antifibrotic and renoprotective activities. 4L2-P13D can be used in the research of renal fibrosis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 90.1%
- Fòrmula: C89H123N19O23S
- Peso molecular:1859.11
-
Almacenamiento:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
4L2-P13D (0.5-5 μM; 72 h) reduces the expression of profibrotic factors (FN1, COL1A1) in TGF-β1-induced HK-2 cells in a dose-dependent manner[1].
4L2-P13D (0-50 μM; 24 h) exhibits no cytotoxicity against HK-2 cells even at concentrations as high as 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:TGF-β1-induced human proximal tubular epithelial (HK-2) cells
-
Concentration:0.5, 2 and 5 μM
-
Incubation Time:72 h
-
Result:Dose-dependently reduced fibronectin (FN1) and type I collagen (COL1A1) expression.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (male, 6-8 weeks old, UUO model)[1]
-
Dosage:0.5 mg/kg; 2 mg/kg
-
Administration:s.c.; daily; 7 days
-
Result:Significantly reduced expression levels of fibrosis markers FN1 and α-smooth muscle α-SMA.
Remarkably reduced proinflammatory markers (TNF-α, TGF-β1, IL-6, IL-1β) and kidney injury markers (Kim1, Ngal).
Reduced blood urea nitrogen (BUN) and creatinine levels.
Significantly improved collagen deposition, with the high-dose group showing superior efficacy compared to the low-dose group.
Chemical Information
-
Appearance Solid
-
Peso molecular 1859.11
-
Fòrmula C89H123N19O23S
-
Color White to off-white
-
Sequence
Ac-Tyr-Leu-Ile-Gln-His-Tyr-Tyr-Thr-Phe-Ile-Ala-Leu-Asp-Cys-Gly-NH2 (sulfide bridge: Tyr1-Cys14)
-
Sequence Shortening
Ac-YLIQHYYTFIALDCG-NH2 (sulfide bridge: Tyr1-Cys14)
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureza y Documentación
-
Ficha de datos (263 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4L2-P13D Related Classifications
HY-P11623 Related Classifications
Powered by Bioz