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NBQX

(Synonyms: FG9202)
23 Cited Publications
Revisión del cliente

Based on 23 publication(s) in Google Scholar

NBQX (FG9202) is a highly selective and competitive AMPA receptor antagonist. NBQX has neuroprotective and anticonvulsant activity.

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  • Pureza: 99.82%
  • No. CAS: 118876-58-7
  • Fòrmula: C12H8N4O6S
  • Peso molecular:336.28
  • Almacenamiento:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • NBQX Chemical Structure
    NBQX Chemical Structure
  • Experimental Validation Results for NBQX
  • Experimental Validation Results for NBQX
  • Experimental Validation Results for NBQX
  • Experimental Validation Results for NBQX
  • Experimental Validation Results for NBQX
  • Experimental Validation Results for NBQX
No. CAS: 118876-58-7
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Encuentre su distribuidor local Your local distributor: Hycultec GmbHHycultec
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  • NBQX Chemical Structure
    NBQX Chemical Structure
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  • 1/16

    NBQX purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr:139:156457. [Abstract]

    Customer Validation
     Representative images of FJB-positive neurons, marking degenerating neurons in the CA1, CA3, and DG regions post-TBI. The results showed that, compared with the TBI‑vehicle group, the NBQX (30 mg/kg) treatment group exhibited a significant reduction in neuronal death in the CA1, CA3, and DG regions of the rat hippocampus.

  • 1/16

    NBQX purchased from MedChemExpress. Usage Cited in: Nature. 2024 Jul;631(8022):826-834. [Abstract]

    Customer Validation
     Representative images showing the calcein-PI staining of cultured neurons from Asic1a+/+ and Asic1a-/- mice with different treatments. GluR-B: glutamate receptor blockers consisted of 50 μM D-AP5, 10 μM NBQX and 10 μM LY341495.

  • 1/16

    NBQX purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080. [Abstract]

    Customer Validation
     NBQX (1 mg/kg/d; i.p.; once daily for 4 weeks). UNEL showed that activation of AMPAR increased cardiomyocyte apoptosis in vitro, but incubation with a NF-κB-specific inhibitor BAY 11-7082 reversed this effect.

  • 1/16

    NBQX purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080. [Abstract]

    Customer Validation
     NBQX (NB, 1 mg/kg/d; i.p.; once daily for 4 weeks). Apoptosis measurement by flow cytometry shows that activation of AMPAR increased apoptosis, but this effect was reversed by BAY 11-7082.

  • 1/16

    NBQX purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2024 May 30:133:112080. [Abstract]

    Customer Validation
     NBQX (NB, 30 μM; added to the medium 6 h before hypoxia stimulation). ELISA method was employed to evaluate TNF-α, IL-1β, IL-6 and IL-10 levels in the culture medium of each group(n = 6). Inhibition of AMPA receptor decreased pro-inflammatory factor production and increased anti-inflammatory factor production. *:p < 0.05;**:p < 0.01;***:p < 0.005; ****:p < 0.001.

  • 1/16

    NBQX purchased from MedChemExpress. Usage Cited in: Theranostics. 2023 May 11;13(9):2946-2961. [Abstract]

    Customer Validation
     NBQX (10 nmol/mL, 1 µl /side, via microinjection into the mPFC) and D-AP5 effectively reduce the express of CaMKIIα, pCREB/CREB, BDNF, and TrkB in mPFC, while activation of HPC-mPFC prevents the decrease (* LPS+CNO versus LPS, # LPS+NBQX/D-AP5+CNO versus LPS+CNO). Data were presented as mean ± SEM. n=5/group. * p < 0.05, ** p < 0.01, # p<0.05, ## p<0.01.

  • NBQX