ACT-281959
ACT-281959 is an orally active prodrug of Selatogrel (HY-109122), a P2Y12 receptor antagonist. ACT-281959 can inhibit platelet aggregation and can be used for the research of cardiovascular disease.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1159501-31-1
- Fòrmula: C38H55N6O14P
- Peso molecular:850.85
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas P2Y Receptor
More
Actividad biológica
|
P2Y12 Receptor |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
8 nM
Compound: ACT-281959
|
Antiplatelet activity in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 2 mins followed by ADP addition for 5 mins
Antiplatelet activity in human platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 2 mins followed by ADP addition for 5 mins
|
[PMID: 34731765] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 1159501-31-1
-
Peso molecular 850.85
-
Fòrmula C38H55N6O14P
-
SMILES
O=C(N1CCN(C([C@@H](NC(C2=NC(C3=CC=CC=C3)=NC(N4C[C@@H](OC)CC4)=C2)=O)CP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)=O)CC1)OCCCC
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Caroff E, et al. 4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. J Med Chem. 2015 Dec 10;58(23):9133-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ACT-281959 Related Classifications
HY-119085 Related Classifications
Powered by Bioz