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Referencia número: HY-120181

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AGI-14100

AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC₅₀=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors.

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No. CAS: 1448346-43-7
Fòrmula: C₂₉H₂₂ClF₄N₅O₃
Peso molecular:599.96

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

AGI-14100 Chemical Structure

No. CAS: 1448346-43-7

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Actividad biológica

Descripciòn

IC₅₀ & Target

mIDH

6 nM (IC₅₀)

Ver todos los productos específicos de isoformas Isocitrate Dehydrogenase (IDH) :

IDH1
IDH2

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	IC₅₀	0.76 nM Compound: 10; AGI-14100	Antiproliferative activity against human HT1080 cells transfected with IDH1 R132H mutant Antiproliferative activity against human HT1080 cells transfected with IDH1 R132H mutant	[PMID: 29847930]
TF-1	IC₅₀	1.75 nM Compound: 10; AGI-14100	Antiproliferative activity against human TF1 cells transfected with IDH1 R132H mutant Antiproliferative activity against human TF1 cells transfected with IDH1 R132H mutant	[PMID: 29847930]
U-87MG ATCC	IC₅₀	0.74 nM Compound: 10; AGI-14100	Antiproliferative activity against human U87MG cells transfected with IDH1 R132H mutant Antiproliferative activity against human U87MG cells transfected with IDH1 R132H mutant	[PMID: 29847930]

Chemical Information

No. CAS 1448346-43-7
Peso molecular 599.96
Fòrmula C₂₉H₂₂ClF₄N₅O₃
SMILES

O=C([C@@H](N1C2=NC=CC(C#N)=C2)CCC1=O)N([C@@H](C3=CC=CC=C3Cl)C(NC4CC(C4)(F)F)=O)C5=CC(F)=CC(F)=C5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Popovici-Muller J, et al. Discovery of AG-120 (Ivosidenib): a first-in-class mutant IDH1 inhibitor for the treatment of IDH1 mutant cancers[J]. ACS medicinal chemistry letters, 2018, 9(4): 300-305. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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AGI-14100

Ver todos los productos específicos de isoformas Isocitrate Dehydrogenase (IDH)

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

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AGI-14100 Related Classifications

HY-120181 Related Classifications