AM-7209
AM-7209 is a potent and selective MDM2-p53 interaction inhibitor with a Kd of 38 pM. AM-7209 inhibits the MDM2 amplified SJSA-1 osteosarcoma cell line with an IC50 of 1.6 nM. AM-7209 shows antitumor activities.
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- No. CAS: 1623432-51-8
- Fòrmula: C37H41Cl2FN2O7S
- Peso molecular:747.70
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | ED50 |
10 mg/kg
Compound: 25, AM-7209
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Antitumor activity against human HCT116 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd starting on day 10 of tumor implantation
Antitumor activity against human HCT116 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd starting on day 10 of tumor implantation
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[PMID: 25384157] |
| HCT-116 | IC50 |
>25 μM
Compound: 25, AM-7209
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Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay
Antiproliferative activity p53 -deficient human HCT116 cells after 16 hrs by BrdU proliferation assay
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[PMID: 25384157] |
| HCT-116 | IC50 |
2 nM
Compound: 25, AM-7209
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Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay
Antiproliferative activity against human HCT116 cells expressing p53 wild type after 16 hrs by BrdU proliferation assay
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[PMID: 25384157] |
| SJSA-1 | ED50 |
2.6 mg/kg
Compound: 25, AM-7209
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Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days
Antitumor activity against human SJSA1 cells xenografted in athymic nude mouse assessed as tumor growth inhibition administered orally qd for 4 days
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[PMID: 25384157] |
Chemical Information
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No. CAS 1623432-51-8
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Peso molecular 747.70
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Fòrmula C37H41Cl2FN2O7S
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SMILES
O=C(O)C1=CC=C(NC(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)=O)C=C1OC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM-7209 Related Classifications
HY-12941 Related Classifications
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